Results 11 to 20 of about 148,552 (285)

Voriconazole Compared with Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Neutropenia and Persistent Fever [PDF]

New England Journal of Medicine, 2002
Background Patients with neutropenia and persistent fever are often treated empirically with amphotericin B or liposomal amphotericin B to prevent invasive fungal infections.
Donowitz, Gerald, Greenberg, Richard, Lazarus, Hillard M., Lee, Jeanette, Pappas, Peter, Petersen, Finn, Raffalli, John, Stiff, Patric, Walsh, Thomas J., Winston, Drew J., Yanovich, Saul   +10 more
core   +4 more sources

Lipase-Responsive Amphotericin B Loaded PCL Nanoparticles for Antifungal Therapies

Nanomaterials, 2022
Amphotericin B is an antifungal drug used for the treatment of invasive fungal infections. However, its clinical use is limited due to its serious side effects, such as renal and cardiovascular toxicity.
Evelyn Osehontue Uroro, Richard Bright, Andrew Hayles, Krasimir Vasilev   +3 more
doaj   +1 more source

Drug-induced hypersensitivity syndrome by liposomal amphotericin-B: a case report [PDF]

, 2015
BACKGROUND: Liposomal amphotericin-B (Ambisome(®)) is widely used antifungal drug for treatments of invasive fungal infections. The use of liposomal amphotericin-B is increasing in medical setting because of its tolerability and potent antifungal ...
Hideo Kato, Hiroshige Mikamo, Jun Hirai, Katsuhiko Matsuura, Mao Hagihara, Yuka Yamagishi, Yukihiro Hamada, Yusuke Koizumi   +7 more
core   +1 more source

Limited Activity Of Miltefosine In Murine Models Of Cryptococcal Meningoencephalitis And Disseminated Cryptococcosis [PDF]

, 2013
Miltefosine is an alkyl phosphocholine with good oral bioavailability and in vitro activity against Cryptococcus species that has gained interest as an additional agent for cryptococcal infections.
Bocanegra, Rosie, Kirkpatrick, William R., Najvar, Laura K., Patterson, Thomas F., Sorrell, Tania C., Wiederhold, Nathan P.   +5 more
core   +1 more source

Therapeutic Drug Monitoring of Amphotericin-B in Plasma and Peritoneal Fluid of Pediatric Patients after Liver Transplantation: A Case Series

Antibiotics, 2022
Fungal infections represent a serious complication during the post-liver transplantation period. Abdominal infections can occur following pre-existing colonization, surgical procedures, and permanence of abdominal tubes.
Francesca Tortora, Luigi Dei Giudici, Raffaele Simeoli, Fabrizio Chiusolo, Sara Cairoli, Paola Bernaschi, Roberto Bianchi, Sergio Giuseppe Picardo, Carlo Dionisi Vici, Bianca Maria Goffredo   +9 more
doaj   +1 more source

Limited effectiveness of high-dose liposomal amphotericin B (AmBisome) for treatment of visceral leishmaniasis in an Ethiopian population with high HIV prevalence. [PDF]

, 2011
Due to unacceptably high mortality with pentavalent antimonials, Médecins Sans Frontières in 2006 began using liposomal amphotericin B (AmBisome) for visceral leishmaniasis (VL) patients in Ethiopia who were severely ill or positive for human ...
Aderie, Endashaw Mengistu, Chane, Solomon, Collin, Simon M, Davidson, Robert N, Piening, Turid, Ritmeijer, Koert, ter Horst, Rachel   +6 more
core   +2 more sources

Combination Antifungal Therapy for Cryptococcal Meningitis [PDF]

, 2013
Background Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized,
Baker, Stephen G., Campbell, James I., Chau, Nguyen V.V., Chau, Tran T.H., Chuong, Ly V., Day, Jeremy N., Diep, Pham T., Dung, Nguyen T., Duong, Van A., Farrar, Jeremy J., Hien, Tran T., Hoang, Thu N., Lalloo, David, Mai, Nguyen H., Mai, Pham P., Nghia, Ho D., Phong, Nguyen D., Phu, Nguyen H., Sieu, Tran P.M., Sinh, Dinh X., Thai, Cao Q., Thai, Le H., Wolbers, Marcel   +22 more
core   +1 more source

Taming Amphotericin B [PDF]

Bioconjugate Chemistry, 2015
A strategy is introduced for enhancing the cellular selectivity of Amphotericin B (AmB) and other classes of membrane-disrupting agents. This strategy involves attaching the agent to a molecular umbrella to minimize the disruptive power of aggregated forms. Based on this approach, AmB has been coupled to a molecular umbrella derived from one spermidine
Vaclav, Janout, Wiley A, Schell, Damien, Thévenin, Yuming, Yu, John R, Perfect, Steven L, Regen   +5 more
openaire   +2 more sources

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source

Black and white teas as potential agents to combine with amphotericin B and protect red blood cells from amphotericin B-mediated toxicity

Brazilian Journal of Biology, 2018
Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting immunocompromised patients. However, severe side effects have limited the utility of this drug.
V. M. Oliveira, N. M. Khalil, E. Carraro
doaj   +1 more source