Results 21 to 30 of about 95,889 (290)

In Vitro Interaction and Killing-Kinetics of Amphotericin B Combined with Anidulafungin or Caspofungin against Candida auris

Pharmaceutics, 2021
Treatment of invasive infections caused by Candida auris is challenging due to the limited therapeutic options. The combination of antifungal drugs may be an interesting and feasible approach to be investigated.
Unai Caballero, Elena Eraso, Guillermo Quindós, Nerea Jauregizar   +3 more
doaj   +1 more source

Do Ophthalmic Solutions of Amphotericin B Solubilised in 2-Hydroxypropyl-γ-Cyclodextrins Possess an Extended Physicochemical Stability?

Pharmaceutics, 2020
Fungal keratitis is a sight-threatening disease for which amphotericin B eye drops is one of the front-line treatments. Unfortunately, there are currently no commercial forms available, and there is little data concerning the long-term stability of ...
Philip Chennell, Mouloud Yessaad, Florence Abd El Kader, Mireille Jouannet, Mathieu Wasiak, Yassine Bouattour, Valérie Sautou   +6 more
doaj   +1 more source

Pharmacodynamics of Amphotericin B Deoxycholate, Amphotericin B Lipid Complex, and Liposomal Amphotericin B against Aspergillus fumigatus [PDF]

Antimicrobial Agents and Chemotherapy, 2015
ABSTRACT Amphotericin B is a first-line agent for the treatment of invasive aspergillosis. However, relatively little is known about the pharmacodynamics of amphotericin B for invasive pulmonary aspergillosis. We studied the pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAMB), amphotericin B ...
Zaid Al-Nakeeb, Vidmantas Petraitis, Ruta Petraitiene, Joanne Goodwin, Thomas J. Walsh, William W. Hope   +5 more
openaire   +2 more sources

In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B [PDF]

Antimicrobial Agents and Chemotherapy, 1984
The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes
K. Mills, Gabriel Lopez-Berestein, Victor Fainstein, R. L. Juliano, Reeta Mehta, Roy L. Hopfer   +5 more
openaire   +3 more sources

Amphotericin B-Induced Encephalopathy

Pediatric Neurology Briefs, 1995
Three children with refractory leukemia treated by bone marrow transplantation at the Children’s National Medical Center, Washington, DC, developed encephalopathy, leukoencephalopathy, and parkinsonism after receiving high-dose amphotericin B for ...
J Gordon Millichap
doaj   +1 more source

Therapeutic potential of Calotropis gigantea extract against invasive pulmonary aspergillosis: In vitro and in vivo study

Asian Pacific Journal of Tropical Biomedicine, 2022
Objective: To characterize the antifungal activity of methanolic leaf extract of Calotropis gigantea alone or in combination with amphotericin B against invasive pulmonary aspergillosis in mice. Methods: GC/MS was used for analysis of active constituents
Enas M Ali, Manal A Alfwuaires, Gehan M Badr   +2 more
doaj   +1 more source

Efficacy of combination therapy of amphotericin and posaconazole in treatment of mucormycosis

Journal of Applied Pharmaceutical Research, 2023
Background: Mucormycosis is an opportunistic systemic fungal infection which is debilitating caused by order Mucorales. The standard management of mucormycosis consists of aggressive debridement of the infected tissue and parenteral anti-fungal therapy ...
Sridhara S, Ramesh Sanappa, Nandini P, Gayatri Jayan, Gangadhara KS   +4 more
doaj   +1 more source

Comparative Chemotherapeutic Activity of Amphotericin B and Amphotericin B Methyl Ester [PDF]

Antimicrobial Agents and Chemotherapy, 1975
The comparative efficacy of amphotericin B and amphotericin B methyl ester (AME) against experimental histoplasmosis, blastomycosis, cryptococcosis, and candidosis in mice was assessed by determining the effect of daily intraperitoneal therapy on 21-day survival and persistence of organisms in internal organs. AME, like amphotericin B, was
Carl P. Schaffner, Witold Mechlinski, Ram P. Tewari, Daniel P. Bonner, Morris Solotorovsky   +4 more
openaire   +3 more sources

Preventing or attenuating amphotericin B nephrotoxicity with dopamine receptor agonists: a literature review [PDF]

Trends in Pharmaceutical Sciences, 2015
Nephrotoxicity is generally considered as the most clinically significant and dose-limiting adverse reaction of amphotericin B. Currently, only the clinical effectiveness of salt loading and administering lipid formulations of amphotericin B have been ...
Iman Karimzadeh, Hossein Khalili, Mohammad Mahdi Sagheb   +2 more
doaj   +2 more sources

Using single-dose liposomal amphotericin B for cryptococcal meningitis induction therapy: nurse pearls and practical perspectives [version 1; peer review: 2 approved]

Wellcome Open Research
Background In Uganda where the burden of HIV-associated cryptococcal meningitis is high, conventional amphotericin B deoxycholate has been standard to manage patients with cryptococcal meningitis in research settings.
Richard Kwizera, Cynthia Ahimbisibwe, Jane Frances Ndyetukira, David B. Meya, Carol Namujju   +4 more
doaj   +1 more source