Results 1 to 10 of about 228,730 (331)
The neuroprotective effect of Rho-kinase Inhibition in 1-methyl-4-phenylpyridinium (MPP+)-induced cellular model of neurodegeneration [PDF]
Medicinski Podmladak, 2021 Introduction: The 1-methyl 4-phenyl 1,2,3,6-tetrahydropiridium (MPTP) induced model of neurodegeneration in Parkinson's disease (PD) is one of the most commonly used experimental models.
Blagojević Sanja +2 more
doaj +1 more source
Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits
Frontiers in Bioscience-Landmark, 2022 Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
doaj +1 more source
Melatonin postconditioning combined with sitagliptin exerts full cardioprotection in diabetic hearts of aged rats through an AMPK-dependent mechanism [PDF]
Archives of Biological Sciences, 2021 The presence of multiple comorbidities in patients facing myocardial ischemia-reperfusion (IR) injury is the main obstacle for cardioprotection. This study investigated the effect of melatonin postconditioning combined with sitagliptin pretreatment on ...
Song Ronggang +3 more
doaj +1 more source
Low-dose metformin targets the lysosomal AMPK pathway through PEN2
Nature, 2022 Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1 – 4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role in its mechanism of action 4 , 5 ...
Teng Ma +34 more
semanticscholar +1 more source
The AMPK pathway in fatty liver disease
Frontiers in Physiology, 2022 Lipid metabolism disorders are the primary causes for the occurrence and progression of various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) caused by a high-fat diet and ethanol.
Chunqiu Fang +6 more
semanticscholar +1 more source
Redefining the role of AMPK in autophagy and the energy stress response
Nature Communications, 2023 Autophagy maintains cellular homeostasis during low energy states. According to the current understanding, glucose-depleted cells induce autophagy through AMPK, the primary energy-sensing kinase, to acquire energy for survival.
Ji-Man Park, Da-Hye Lee, Do-Hyung Kim
semanticscholar +1 more source
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
Science, 2023 Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effects ...
Nazma Malik +14 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse metabolic and physiological effects besides its fundamental role in glucose ...
C. K. Keerthana +6 more
semanticscholar +1 more source
The role of AMPK in macrophage metabolism, function and polarisation
Journal of Translational Medicine, 2023 AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple aspects of cell metabolism.
Yinxing Cui +5 more
semanticscholar +1 more source
Environmental Health and Preventive Medicine, 2023 Background: In this study, we aimed to investigate the effects of acute and chronic resistance training of varying intensities on molecular responses and their association with muscular fitness in a cohort of young males who participated in this ...
Chongwen Zuo +4 more
doaj +1 more source