Results 21 to 30 of about 117,713 (263)
Effects of Aerobic Interval Training and Adenosine on the Expression of AMPK, PPARγ and A2B Receptor in the Liver of Rats Fed a High-Fat Diet [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Obesity causes steatosis in the liver. PPARγ transcription factor of glucose and fat metabolism genes and AMPK cell energy sensor are considered as therapeutic targets in non-alcoholic fatty liver (NAFLD) patients.
Abolhasan Hedayati katooli +3 more
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STIM2 interacts with AMPK and regulates calcium‐induced AMPK activation [PDF]
The FASEB Journal, 2018 ABSTRACT AMPK is a crucial regulator of energy homeostasis that acts downstream of its upstream kinase liver kinase B1 (LKB1) and calcium/calmodulin‐dependent protein kinase 2 (CaMKK2). LKB1 primarily phosphorylates AMPK after energy stress, whereas calcium‐mediated activation of AMPK requires CaMKK2, although the
Chauhan, Anoop Singh +7 more
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Innovative therapeutic strategies for cardiovascular disease
EXCLI Journal : Experimental and Clinical Sciences, 2023 As a significant non-communicable disease, cardiovascular disease is the leading cause of death for both men and women, comprises almost twenty percent of deaths in most racial and ethnic groups, can affect greater than twenty-five million individuals ...
Kenneth Maiese
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L-carnitine administration effects on AMPK, APPL1 and PPARγ genes expression in the liver and serum adiponectin levels and HOMA-IR in type 2 diabetes rat model induced by STZ and nicotinamide [PDF]
The Ukrainian Biochemical Journal, 2020 Diabetes is a chronic disease and a public health problem globally. L-Carnitine is synthesized in the liver, promotes fatty acids oxidation and currently is used as a supplement against weight gain.
B. Shahouzehi +2 more
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Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b
Clinical and Experimental Hypertension, 2017 Background: Berberine has several preventive effects on cardiovascular diseases. Increased expression of miR-29b has been reported to attenuate cardiac remodeling after myocardial infarction (MI).
Mo-Li Zhu +6 more
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Choreography of AMPK activation [PDF]
Cell Research, 2014 A recent study published in Cell Research by Li and colleagues reports a detailed biophysical and structural study of AMPK's intra-molecular interactions during activation. By employing subunit tagging and proximity analysis with the aid of AlphaScreen instrumentation, Li et al. add to our understanding of the choreography of activation of AMPK by both
Langerdorf, Christopher G. +1 more
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Molecules, 2020 Adenosine -5′-triphosphate (ATP) plays a valuable role in metabolic activity to produce adequate energy in a biosystem. A high ATP/AMP ratio has a correlation with diabetes that induces suppression of AMP-activated protein kinase (AMPK).
Chih-Hao Lin +3 more
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AMP-activated protein kinase: a therapeutic target in intestinal diseases [PDF]
Open Biology, 2017 Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders.
Xiaofei Sun, Mei-Jun Zhu
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The Journal of Poultry Science, 2022 Protein synthesis in skeletal muscle is considered one of the most energy-consuming cellular processes. AMP-activated protein kinase (AMPK) is a metabolic master switch that regulates glucose and lipid metabolism, and it is implicated in protein ...
Kazuki Nakashima, Aiko Ishida
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A new duet in cancer biology: AMPK the typical and UBE2O the atypical
Molecular & Cellular Oncology, 2017 Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1–hypoxia ...
Isabelle K. Vila +2 more
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