Results 11 to 20 of about 117,713 (263)
Communicative & Integrative Biology, 2012 Ion transport processes are highly energy consuming. It is therefore critical to couple ion transport processes to the metabolic state of the cell. An important player in this coupling appears to be the AMP-activated protein kinase (AMPK). This kinase becomes activated during conditions of cellular metabolic stress and is well-known for its role in ...
Andersen, Martin Nybo +1 more
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IQGAP1 binds AMPK and is required for maximum AMPK activation [PDF]
Journal of Biological Chemistry, 2021 AMP-activated protein kinase (AMPK) is a fundamental component of a protein kinase cascade that is an energy sensor. AMPK maintains energy homeostasis in the cell by promoting catabolic and inhibiting anabolic pathways. Activation of AMPK requires phosphorylation by the liver kinase B1 or by the Ca2+/calmodulin-dependent protein kinase 2 (CaMKK2).
Andrew C. Hedman +5 more
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Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation [PDF]
International Journal of Molecular Sciences, 2020 A role for the cytoplasmic protein synphilin-1 in regulating energy balance has been demonstrated recently. Expression of synphilin-1 increases ATP levels in cultured cells. However, the mechanism by which synphilin-1 alters cellular energy status is unknown.
Tianxia Li +8 more
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, 2016 During host-pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host immunity against infection.
Mesquita, Inês +7 more
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NF-κB signaling and crosstalk during carcinogenesis
4 open, 2019 Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M. +2 more
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The Roles of AMPK in Revascularization [PDF]
Cardiology Research and Practice, 2020 Coronary heart disease (CHD) is the most common and serious illness in the world and has been researched for many years. However, there are still no real effective ways to prevent and save patients with this disease. When patients present with myocardial infarction, the most important step is to recover ischemic prefusion, which usually is accomplished
Ming-Hong Chen, Qiong-Mei Fu
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Frontiers in Physiology, 2022 Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that involves an intracellular degradation system in which cytoplasmic components, such as protein aggregates, organelles, and other macromolecules, are directed to ...
Shengyuan Wang +16 more
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The Role of AMPK Signaling in Ulcerative Colitis
Drug Design, Development and Therapy, 2023 Yuyi Yuan,1,* Fang Wang,2,* Xingxing Liu,1,* Bo Shuai,1 Heng Fan1 1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022,
Yuan Y, Wang F, Liu X, Shuai B, Fan H
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Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
Pharmaceutical Biology, 2019 Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD).
Xuehong Lu +4 more
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Journal of Applied Animal Research, 2021 Muscle fiber is the basic unit of skeletal muscle. Muscle fiber types play a crucial role in improving meat quality. In the current study, Wistar rats were chronic injected with 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) for four weeks ...
Yanru Hou +7 more
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