Results 141 to 150 of about 890,396 (390)

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

The Synthesis Of Multi-channel Amplifiers. [PDF]

, 1957
Ben F. Barton
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Bandwidth-Tunable Optical Amplifier with Narrowband Filtering Function Enabled by Parity-Time Symmetry at Exceptional Points

Photonics
Integrated optical amplifiers are the building blocks of on-chip photonic systems, and they are often accompanied by a narrowband filter to limit noise.
Kunpeng Zhu, Xiaoyan Zhou, Yinxin Zhang, Zhanhua Huang, Lin Zhang   +4 more
doaj   +1 more source

A New Microwave Amplifier [PDF]

, 1957
S. WEINTROUB
openalex   +1 more source

Digital automatic gain amplifier [PDF]

, 1978
A circuit is described for adjusting the amplitude of a reference signal to a predetermined level so as to permit subsequent data signals to be interpreted correctly.
Holley, L. D., Ward, J. O.
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Cylindrical Vector Beams with an MOPA Amplifier Based on Nonlinear Polarization Rotation Mode-Locking

Photonics
CVBs (cylindrical vector beams) are widely used in optical imaging, optical trapping, material processing, etc. In this study, based on mode-selective couplers and passive mode-locking fiber technology, a cylindrical vector fiber amplifier with an MOPA ...
Tianyu Zhang, Dong Li, Siqi Pei, Yun Zhu, Jiapeng Hu, Xuesheng Liu, Anru Yan, Youqiang Liu, Zhiyong Wang   +8 more
doaj   +1 more source

Transistorized Linear Pulse Amplifiers [PDF]

, 1959
Stanley C. Baker
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source