Results 71 to 80 of about 450,311 (295)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Antimicrobial Resistance: Implications and Costs

Infection and Drug Resistance, 2019
Porooshat Dadgostar Milken Institute of Public Health, George Washington University, Washington, DC, USACorrespondence: Porooshat DadgostarMilken Institute of Public Health, George Washington University, Washington, DC, USATel +1-206-696-6474Email ...
Dadgostar P
doaj  

Large-Scale Simulations of Clusters of Galaxies

, 2000
We discuss some of the computational challenges encountered in simulating the evolution of clusters of galaxies. Eulerian adaptive mesh refinement (AMR) techniques can successfully address these challenges but are currently being used by only a few ...
Calder, A. C., Dursi, L. J., Fryxell, B., Lamb, D. Q., MacNeice, P., Olson, K., Ricker, P. M., Rosner, R., Timmes, F. X., Truran, J. W., Tufo, H. M., Zingale, M.   +11 more
core   +2 more sources

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

مطالعه‌ی ناهمسانگردی مغناطیسی در ابرشبکه‌های /Cu Ni-Fe [PDF]

پژوهش سیستم‌های بس‌ذره‌ای, 2012
روش لایه­نشانی الکتروشیمیایی یا الکتروانباشت یکی از ساده­ترین و مفیدترین روش­ها در تهیه­ی فیلم­های نازک آلیاژی و به خصوص چندلایه‌ای‌های فلزی می­باشد. در این کار، از الکترولیتی شامل نمک­های سولفات نیکل، آهن و مس در شرایط متفاوتی از دما و pH استفاده شد و ...
غلامرضا نبیونی, نرگس صفائی, نرگس نوازش   +2 more
doaj  

Evidence for Antiferromagnetic Order in La$_{2-x}$Ce$_{x}$CuO$_{4}$ from Angular Magnetoresistance Measurements

, 2009
We investigated the in-plane angular magnetoresistivity (AMR) of $% T^{^{\prime}}$-phase La$_{2-x}$Ce$_{x}$CuO$_{4}$ (LCCO) thin films ($% x=0.06-0.15$) fabricated by a pulsed laser deposition technique.
A. I. Ponomarev, K. Jin, P. Bach, R. L. Greene, X. H. Zhang   +4 more
core   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

ForestClaw: Hybrid forest-of-octrees AMR for hyperbolic conservation laws

, 2013
We present a new hybrid paradigm for parallel adaptive mesh refinement (AMR) that combines the scalability and lightweight architecture of tree-based AMR with the computational efficiency of patch-based solvers for hyperbolic conservation laws.
Burstedde, Carsten, Calhoun, Donna, Mandli, Kyle, Terrel, Andy R.   +3 more
core   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Organic Thin‐Film Transistors for Neuromorphic Computing

Advanced Electronic Materials, EarlyView.
Organic thin‐film transistors (OTFTs) are reviewed for neuromorphic computing applications, highlighting their power‐efficient, and biological time‐scale operation. This article surveys OFET and OECT devices, compares them with memristors and CMOS, analyzes how fabrication parameters shape spike‐based metrics, proposes standardized characterization ...
Luke McCarthy, Mohan V. Jacob, Mostafa Rahimi Azghadi   +2 more
wiley   +1 more source