Results 171 to 180 of about 12,396 (213)
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Effects of Amylin and the Amylin Agonist Pramlintide on Glucose Metabolism
Diabetic Medicine, 1997Since the discovery of the pancreatic islet hormone amylin in 1987, its metabolic effects have been investigated in a number of studies in animals and humans. Data from some early animal studies suggested that amylin might be associated with the development of insulin resistance, but other studies found that amylin had no effect on insulin sensitivity.
Schmitz, O +4 more
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Current opinion in investigational drugs (London, England : 2000), 2001
Pramlintide is a human amylin analog, under development by Amylin (originally in collaboration with Johnson & Johnson), as an adjunct with insulin for the potential prevention of complications of type I diabetes, and as a single agent for type II diabetes [279804], [295121], [305454].
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Pramlintide is a human amylin analog, under development by Amylin (originally in collaboration with Johnson & Johnson), as an adjunct with insulin for the potential prevention of complications of type I diabetes, and as a single agent for type II diabetes [279804], [295121], [305454].
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Amylin Conjugation with Methoxyl Polyethyleneglycol
Protein & Peptide Letters, 2013We modified amylin chemically by conjugating methoxyl polyethyleneglycol succinimidyl carbonate (mPEGSC) of varying molecular weights (1 kDa, 2 kDa and 5 kDa). The reaction occurred within a few minutes, resulting in at least four distinct PEGylated products.
Mariana F A N, Guterres +4 more
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Science of Aging Knowledge Environment, 2004
Like a retaining wall that protects a beach house from the pounding ocean, a protein called amylin keeps bones strong by preventing their disintegration, new research shows. The results suggest a novel potential therapy against osteoporosis.
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Like a retaining wall that protects a beach house from the pounding ocean, a protein called amylin keeps bones strong by preventing their disintegration, new research shows. The results suggest a novel potential therapy against osteoporosis.
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1994
A biologically active peptide associated with diabetes and designated herein "amylin" and processes for preparing it and assaying for it and for Type 2 diabetes are disclosed. The invention includes peptides having the amino acid sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY, substantially homologous sequences of amino acids, proamylin, as well as ...
Cooper, Garth +2 more
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A biologically active peptide associated with diabetes and designated herein "amylin" and processes for preparing it and assaying for it and for Type 2 diabetes are disclosed. The invention includes peptides having the amino acid sequence KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY, substantially homologous sequences of amino acids, proamylin, as well as ...
Cooper, Garth +2 more
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Functional study of amylin and regulation of amylin receptor
2010Amylin, a 37 amino acid peptide secreted from pancreatic beta cells upon stimulation by meal/glucose, belongs to the family of the calcitonin or calcitonin gene-related peptide (CGRP) and shares up to 50% homology with CGRP, which is a well-documented pain-related peptide.
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Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus
Nature Reviews EndocrinologyChristopher S Walker +4 more
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Amylin and amylin receptors in Alzheimer's disease
2020Wen Fu, Jack H. Jhamandas
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Skin Capillary Amylin Deposition Resembles Brain Amylin Vasculopathy (S33.003)
Neurology, 2022Saurav Das +5 more
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