Results 1 to 10 of about 2,028,099 (219)
In silico study about β-amyloid’s role in Alzheimer’s disease and glaucoma and prediction of its interactions with glaucoma related proteins [PDF]
Exploration of Drug Science, 2023 Aim: The significance of β-amyloid protein as a key player in neuro-degenerative disorders viz. Alzheimer’s disease (AD), Parkinson’s disease (PD) has been extensively researched and reported.
Nancy Maurya
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Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner. [PDF]
PLoS ONE, 2010 Amyloid-β interacts with two cell surface receptors, CD36 and CD47, through which the matricellular protein thrombospondin-1 inhibits soluble guanylate cyclase activation. Here we examine whether amyloid-β shares this inhibitory activity.
Thomas W Miller +4 more
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The Amyloid-β Pathway in Alzheimer’s Disease
Molecular Psychiatry, 2021 Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure,
H. Hampel +14 more
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Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future
Signal Transduction and Targeted Therapy, 2023 Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.
Yun Zhang +4 more
semanticscholar +1 more source
eLife, 2020 The brains of Alzheimer’s disease patients show a decrease in brain mass and a preponderance of extracellular Amyloid-β plaques. These plaques are formed by aggregation of polypeptides that are derived from the Amyloid Precursor Protein (APP).
Chu Hsien Lim +8 more
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Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling. [PDF]
PLoS ONE, 2018 Amyloid formation in the pancreatic islets due to aggregation of human islet amyloid polypeptide (hIAPP) contributes to reduced β-cell mass and function in type 2 diabetes (T2D) and islet transplantation. Protein kinase B (PKB) signaling plays a key role
Yun Zhang +6 more
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BMC Neurology, 2022 Background: What combination of risk factors for Alzheimer’s disease (AD) are most predictive of cognitive decline in cognitively unimpaired individuals remains largely unclear.
Jori Tomassen +14 more
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A β-Amyloid(1-42) Biosensor Based on Molecularly Imprinted Poly-Pyrrole for Early Diagnosis of Alzheimer’s Disease [PDF]
Journal of Biomedical Physics and Engineering, 2021 Background: Alzheimer’s disease (AD) is a common form of dementia, characterized by production and deposition of β-amyloid peptide in the brain. Thus, β-amyloid peptide is a potentially promising biomarker used to diagnose and monitor the progression of ...
Rezvan Dehdari Vais +3 more
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Frontiers in Aging Neuroscience, 2021 Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques.
Claudia Schwarz +15 more
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Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Nature, 2023 Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease. The incidence of Alzheimer’s disease (AD), the leading cause of dementia,
Constanze Depp +29 more
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