Results 111 to 120 of about 2,028,198 (315)

Differential effects of APOE2 and APOE4 alleles on PET‐measured amyloid‐β and tau deposition in older individuals without dementia [PDF]

, 2020
Michel J. Grothe, Gemma Salvadó, Colin Groot, Alexis Moscoso, Juan Domingo Gispert, Michael Schöll, Rik Ossenkoppele   +6 more
openalex   +1 more source

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Science Translational Medicine, 2012
Jeffrey J. Iliff, Minghuan Wang, Yonghong Liao, Benjamin A. Plogg, Weiguo Peng, G. A. Gundersen, H. Benveniste, G. E. Vates, R. Deane, S. Goldman, E. Nagelhus, M. Nedergaard   +11 more
semanticscholar   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Potential effect of nanoformulated iota carrageenan in Aβ1-42 disaggregation: an in vitro, in vivo and in silico study

ADMET and DMPK
Background and purpose: Alzheimer's disease is the primary contributor to neurodegenerative conditions. These pathologies are identified by the deposition of β-amyloid peptide within brain regions.
Saranya Udayakumar, Sanjay Kisan Metkar, Koyeli Girigoswami, Agnishwar Girigoswami   +3 more
doaj   +1 more source

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β [PDF]

, 2012
Robert M. Koffie, Tadafumi Hashimoto, Hwan‐Ching Tai, Kevin R. Kay, Alberto Serrano‐Pozo, Daniel Joyner, Steven S. Hou, Katherine J. Kopeikina, Matthew P. Frosch, Virginia M. Lee, David M. Holtzman, Bradley T. Hyman, Tara L. Spires‐Jones   +12 more
openalex   +1 more source

Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases

Advanced Science, EarlyView.
ABSTRACT Previously regarded merely as a potentially harmful waste product of heme catabolism, bilirubin has now emerged as a pleiotropic molecule with potent antioxidant, anti‐inflammatory, and hormone‐like properties. Recent findings have revealed protective effects against cardiovascular, metabolic, autoimmune, and neoplastic diseases, as well as ...
Sri Jayanti, Libor Vítek, Silvia Gazzin, Claudio Tiribelli   +3 more
wiley   +1 more source

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

P1–104: Assessing the effects of memantine in APP/PS1 transgenic mice by behavioral studies and ex vivo imaging of amyloid plaques using gadolinium labeled amyloid β peptides and micromri [PDF]

, 2006
Thomas Wısnıewskı, Henrieta Scholtzova, Youssef Zaim Wadghiri, Einar M. Sigurdsson, Moustafa Douadi, Yongsheng Li, David Quartermain, Pradeep Banerjee   +7 more
openalex   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source