Results 181 to 190 of about 2,028,198 (315)

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, EarlyView.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Disrupting Dimeric β‑Amyloid by Electric Fields

ACS Physical Chemistry Au, 2023
Pablo Andrés Vargas-Rosales, Alessio D’Addio, Yang Zhang, Amedeo Caflisch   +3 more
doaj   +1 more source

OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor

Arthritis &Rheumatology, EarlyView.
Objective To verify the pathogenesis of the opioid growth factor receptor like‐1 (OGFRL1) loss‐of‐function variant (c.30del, p. F10Ffs*110) identified in a patient with chronic recurrent multifocal osteomyelitis (CRMO) and to investigate the underlying mechanism.
Wen Xiong, Yusha Wang, Tingyan He, Jinjian Fu, Ying Luo, Jinbo Wang, Jun Wang, Xiaomin Yu, Qing Zhou, Jun Yang   +9 more
wiley   +1 more source

Amyloid-β Seeds in Alzheimer's Disease: Research Challenges and Implications. [PDF]

J Neurochem
Beschorner N, Xu Y, Jucker M, Ruiz-Riquelme A.   +3 more
europepmc   +1 more source

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1

, 2018
Jenny U. Johansson, William D. Brubaker, Harold S. Javitz, Andrew W. Bergen, Denise Nishita, Abhishek Trigunaite, Andrés B Crane, Justine Ceballos, Diego Mastroeni, Andrea J. Tenner, Marwan N. Sabbagh, Joseph Rogers   +11 more
openalex   +2 more sources

Extracts of Glycyrrhiza uralensis and Isoliquiritigenin Counteract Amyloid-β Toxicity in Caenorhabditis elegans [PDF]

, 2015
Pille Link, Bernhard Wetterauer, Yujie Fu, Michaël Wink   +3 more
openalex   +1 more source

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

Brain : a journal of neurology, 2016
Elizabeth E. Spangenberg, Rafael J. Lee, A. Najafi, Rachel A. Rice, M. Elmore, Mathew Blurton‐Jones, B. West, K. Green   +7 more
semanticscholar   +1 more source

A multifaceted interplay between hemophagocytosis, IL‐18 and type I IFN distinguishes Still disease from other autoinflammatory diseases

Arthritis &Rheumatology, Accepted Article.
Objectives The unknown pathophysiology and the lack of specific features for systemic Juvenile Idiopathic arthritis and adult‐onset Still disease (collectively Still disease/SD) delays diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory diseases ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G.B. Grashof, Laurie Vaillant, Renske J.H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, ImmunAID consortium, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +17 more
wiley   +1 more source

Amyloid-β fibrils accumulated in preeclamptic placentas suppress cytotrophoblast syncytialization. [PDF]

Life Sci Alliance
Nishioka K, Ikezaki M, Iwahashi N, Arakawa M, Fukushima M, Mori N, Mizoguchi M, Horiuchi-Tanizaki Y, Fujino M, Tomiyama T, Ihara Y, Uchimura K, Ino K, Nishitsuji K.   +13 more
europepmc   +1 more source

A drug targeting intracellular amyloid-β and oxidative stress: Apomorphine

, 2011
Yasumasa Ohyagi
openalex   +2 more sources