Results 11 to 20 of about 2,028,198 (315)

Cryo-EM structures of amyloid-β 42 filaments from human brains

Science, 2022
Description Hi-res view of human Aβ42 filaments Alzheimer’s disease is characterized by a loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain. The assembly of Aβ peptides into filaments that end at residue
Yang Yang, Diana Arseni, Wenjuan Zhang, Melissa Huang, Sofia Lövestam, M. Schweighauser, A. Kotecha, A. Murzin, Sew Y. Peak-Chew, Jennifer Macdonald, I. Lavenir, H. Garringer, E. Gelpí, K. Newell, G. Kovacs, R. Vidal, B. Ghetti, B. Ryskeldi-Falcon, S. Scheres, M. Goedert   +19 more
semanticscholar   +1 more source

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

Alzheimer's Research & Therapy, 2011
The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by mitochondrial dysfunction, but the mechanisms underlying this dysfunction ...
Anne Eckert, K. Schmitt, Jürgen Götz
semanticscholar   +1 more source

Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion

Neurobiology of Disease, 1998
Mutations in theamyloid β precursor protein(APP) gene cosegregate with autosomal dominant Alzheimer disease (AD). Brain pathology of AD is characterized by amyloid deposition in senile plaques and by neurofibrillary tangles. Amyloid deposits in AD brains
Chris De Jonghe, Cynthia Zehr, Debra Yager, Cristian-Mihail Prada, Steven Younkin, Lydia Hendriks, Christine Van Broeckhoven, Christopher B. Eckman   +7 more
doaj   +1 more source

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease

Brain : a journal of neurology, 2021
Although recent clinical trials targeting amyloid-β in Alzheimer’s disease have shown promising results, there is increasing evidence suggesting that understanding alternative disease pathways that interact with amyloid-β metabolism and amyloid pathology
J. Pereira, S. Janelidze, Ruben Smith, N. Mattsson‐Carlgren, S. Palmqvist, C. Teunissen, H. Zetterberg, E. Stomrud, N. Ashton, K. Blennow, O. Hansson   +10 more
semanticscholar   +1 more source

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau

EMBO Molecular Medicine, 2021
Alzheimer’s disease is characterized by β‐amyloid plaques and tau tangles. Plasma levels of phospho‐tau217 (P‐tau217) accurately differentiate Alzheimer’s disease dementia from other dementias, but it is unclear to what degree this reflects β‐amyloid ...
Niklas Mattsson‐Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansson   +10 more
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In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells. [PDF]

PLoS ONE, 2017
The progression of Alzheimer's disease is causatively linked to the accumulation of amyloid-β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells.
Jekaterina Krishtal, Olga Bragina, Kristel Metsla, Peep Palumaa, Vello Tõugu   +4 more
doaj   +1 more source

Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2017
Introduction Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Methods Free and total Aβ42/40 plasma ratios (FP42/40 and
Noelia Fandos, Virginia Pérez‐Grijalba, Pedro Pesini, Salvador Olmos, Matías Bossa, Victor L. Villemagne, James Doecke, Christopher Fowler, Colin L. Masters, Manuel Sarasa, AIBL Research Group   +10 more
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Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

Acta Neuropathologica, 2021
Alzheimer’s disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads.
E. Gerrits, N. Brouwer, S. Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, J. Mulder, Markus P Kummer, T. Möller, K. Biber, W. Dunnen, P. D. de Deyn, B. Eggen, E. Boddeke   +13 more
semanticscholar   +1 more source

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

Nature, 2022
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age 1 , 2 , making it the most common amyloid currently known.
J. Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos N. Louros, Katerina Konstantoulea, Angelos A. Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, M. De Vleeschouwer, Hannah A Davies, J. Madine, Deborah Kronenberg-Versteeg, R. Feederle, D. Del Turco, K. Nilsson, T. Lashley, T. Deller, M. Gearing, L. Walker, P. Heutink, F. Rousseau, J. Schymkowitz, M. Jucker, J. Neher   +28 more
semanticscholar   +1 more source

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions

Neurobiology of Disease, 2013
Deposition of amyloid β (Aβ) containing plaques in the brain is one of the neuropathological hallmarks of Alzheimer's disease (AD). It has been suggested that modulation of neuronal activity may alter Aβ production in the brain.
Xuejing Li, Kengo Uemura, Tadafumi Hashimoto, Navine Nasser-Ghodsi, Muriel Arimon, Christina M. Lill, Isabella Palazzolo, Dimitri Krainc, Bradley T. Hyman, Oksana Berezovska   +9 more
doaj   +1 more source