Results 21 to 30 of about 2,028,198 (315)
Journal of Biological Chemistry, 2005 Alzheimer's disease (AD) involves amyloid β (Aβ) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption.
Fusheng Yang +10 more
semanticscholar +1 more source
Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy.
PLoS ONE, 2015 Alzheimer´s disease (AD) is the most common neurodegenerative disorder. AD neuropathology is characterized by intracellular neurofibrillary tangles and extracellular β-amyloid deposits in the brain.
Nina Jährling +5 more
doaj +1 more source
Protective properties of lysozyme on β-amyloid pathology: implications for Alzheimer disease
Neurobiology of Disease, 2015 The hallmarks of Alzheimer disease are amyloid-β plaques and neurofibrillary tangles accompanied by signs of neuroinflammation. Lysozyme is a major player in the innate immune system and has recently been shown to prevent the aggregation of amyloid-β1-40
Linda Helmfors +11 more
doaj +1 more source
Nature Communications, 2021 Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators.
Hafsa Munir +7 more
semanticscholar +1 more source
α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP.
PLoS ONE, 2017 α-Synuclein misfolding and aggregation is often accompanied by β-amyloid deposition in some neurodegenerative diseases. We hypothesised that α-synuclein promotes β-amyloid production from APP.
Hazel L Roberts +2 more
doaj +1 more source
Amyloid‐β PET and CSF in an autopsy‐confirmed cohort
Annals of Clinical and Translational Neurology, 2020 Objective Accumulation of amyloid‐β is among the earliest changes in Alzheimer’s disease (AD). Amyloid‐β positron emission tomography (PET) and Aβ42 in cerebrospinal fluid (CSF) both assess amyloid‐β pathology in‐vivo, but 10–20% of cases show discordant
Juhan Reimand +8 more
doaj +1 more source
Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein
Cell Reports, 2016 Development of disease-modifying therapeutics is urgently needed for treating Alzheimer disease (AD). AD is characterized by toxic β-amyloid (Aβ) peptides produced by β- and γ-secretase-mediated cleavage of the amyloid precursor protein (APP).
Saoussen Ben Halima +10 more
doaj +1 more source
Molecular Metabolism, 2017 Objectives: β-cell dysfunction and apoptosis associated with islet inflammation play a key role in the pathogenesis of type 2 diabetes (T2D). Growing evidence suggests that islet amyloid, formed by aggregation of human islet amyloid polypeptide (hIAPP ...
Queenie Hui +6 more
doaj +1 more source
Copper Chelation via beta-alanine extends lifespan in a C. elegans model of Alzheimer's Disease
Brain Disorders, 2023 The leading hypothesis for Alzheimer's Disease (AD) has traditionally focused on the aggregation of Amyloid-β into amyloid plaques. However, research has yet to definitively prove the role of the amyloid peptide in the pathology of the disease.
Arnulfo Pulido +10 more
doaj +1 more source
Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7
Frontiers in Molecular Neuroscience, 2020 The P2X7 receptor (P2X7) is a cell surface ligand-gated ion channel, activated by its physiological nucleotide agonist ATP and a synthetic analog (BzATP).
Lučka Bibič, Leanne Stokes
doaj +1 more source