Results 291 to 300 of about 2,028,198 (315)

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Nature, 2017
C. Venegas, Sathish Kumar, B. S. Franklin, T. Dierkes, Rebecca Brinkschulte, Darío Tejera, A. Vieira-Saecker, S. Schwartz, Francesco Santarelli, Markus P Kummer, A. Griep, E. Gelpí, Michael Beilharz, D. Riedel, D. Golenbock, M. Geyer, J. Walter, E. Latz, M. Heneka   +18 more
semanticscholar   +1 more source

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Nature Reviews Drug Discovery, 2022
Eric Karran, Bart De Strooper
exaly  

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Nature Medicine, 1996
D. Scheuner, C. Eckman, C. Eckman, M. Jensen, X. Song, M. Citron, N. Suzuki, T. Bird, J. Hardy, M. Hutton, W. Kukull, Eric B. Larson, E. Levy-Lahad, M. Viitanen, E. Peskind, P. Poorkaj, G. Schellenberg, R. Tanzi, W. Wasco, L. Lannfelt, D. Selkoe, S. Younkin   +21 more
semanticscholar   +1 more source

Structural evolution of fibril polymorphs during amyloid assembly

Cell, 2023
Neil A Ranson
exaly  

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Nature Reviews Drug Discovery, 2011
Eric Karran, Bart De Strooper
exaly  

The amyloid state and its association with protein misfolding diseases

Nature Reviews Molecular Cell Biology, 2014
Tuomas P J Knowles, Michele Vendruscolo, Christopher M Dobson   +2 more
exaly  

Therapeutic strategies for human amyloid diseases

Nature Reviews Drug Discovery, 2002
James C Sacchettini
exaly  

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Cell, 2019
Bradlee L Heckmann, Bart Tummers, Emilio Boada-Romero   +2 more
exaly  

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

Nature Reviews Neuroscience, 2019
R. van der Kant, L. Goldstein, R. Ossenkoppele   +2 more
semanticscholar   +1 more source

The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex

Cell, 2018
Miguel Mompeán, Jixi Li, Ansgar B Siemer   +2 more
exaly