Results 101 to 110 of about 514,761 (295)

Redox‐Active Polyphenol Red Molecularly Imprinted Polymers on Porous Gold Electrodes for Ultrasensitive, AI‐Assisted Detection of Alzheimer's Biomarkers in Undiluted Biofluids

Advanced Healthcare Materials, EarlyView.
This work presents a low‐cost, reagent‐free point‐of‐care biosensor integrating redox‐active polyphenol red molecularly imprinted polymers (pPhR MIPs) on highly porous gold (HPG) electrodes for ultrasensitive detection of phosphorylated tau 181 (p‐Tau 181), an Alzheimer’s disease biomarker, in undiluted biofluids.
Sudhaunsh Deshpande, Ajith Mohan Arjun, Guoyi Liu, Kryztof Pawlak, Sanjiv Sharma   +4 more
wiley   +1 more source

Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein [PDF]

, 2008
BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ligands of the liver X receptors
Abraham, Carmela R., Chen, Ci-Di, Cordy, Joanna M., Guillily, Maria, Ray, William J., Seabrook, Guy R., Suon, Sokreine, Wolozin, Benjamin, Zerbinatti, Celina V.   +8 more
core   +4 more sources

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

JAMA Neurology, 2019
Key Points Question Is cognitive decline associated with amyloid-β or tau tangles accumulation? Findings In this cohort study that included 60 normal older adults with repeated positron emission tomography measures, the rate of tau accumulation in the ...
Bernard J. Hanseeuw, Bernard J. Hanseeuw, R. Betensky, H. Jacobs, H. Jacobs, A. Schultz, J. Sepulcre, J. Becker, Danielle M. Cosio, Michelle E. Farrell, Y. Quiroz, E. Mormino, E. Mormino, R. Buckley, R. Buckley, R. Buckley, K. Papp, K. Papp, Rebecca Amariglio, Rebecca Amariglio, I. Dewachter, I. Dewachter, A. Ivanoiu, A. Ivanoiu, W. Huijbers, W. Huijbers, T. Hedden, G. Marshall, G. Marshall, J. Chhatwal, D. Rentz, D. Rentz, R. Sperling, R. Sperling, Keith A. Johnson, Keith A. Johnson   +35 more
semanticscholar   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

Journal of the American Medical Association (JAMA), 2019
Importance Amyloid positron emission tomography (PET) detects amyloid plaques in the brain, a core neuropathological feature of Alzheimer disease. Objective To determine if amyloid PET is associated with subsequent changes in the management of patients ...
G. Rabinovici, C. Gatsonis, Charles Apgar, K. Chaudhary, I. Gareen, Lucy Hanna, James A. Hendrix, B. Hillner, Cynthia Olson, Orit H Lesman-Segev, Justin Romanoff, B. Siegel, R. Whitmer, M. Carrillo   +13 more
semanticscholar   +1 more source

Advancing from MOFs and COFs to Functional Macroscopic Porous Constructs

Advanced Materials, EarlyView.
This review study investigates the recent progress and methodologies for manufacturing metal–organic framework (MOF) or covalent–organic framework (COF)‐based 3D structured macroscopic porous constructs with high structural integrity, providing the possibility to control their porosity across dimensions.
Seyyed Alireza Hashemi, Ahmadreza Ghaffarkhah, Ali Akbar Isari, Mahyar Panahi‐Sarmad, Feng Jiang, Orlando J. Rojas, Stefan Wuttke, Mircea Dincă, Mohammad Arjmand   +8 more
wiley   +1 more source

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

Nature Communications, 2019
The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer’s disease and cerebral amyloid angiopathy. However, the structure of Aβ amyloid fibrils from brain tissue is poorly understood. Here we report the purification of Aβ amyloid
M. Kollmer, William L. Close, Leonie Funk, Jay Rasmussen, Aref Bsoul, A. Schierhorn, Matthias Schmidt, C. Sigurdson, M. Jucker, M. Fändrich   +9 more
semanticscholar   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Dissociation of Alzheimer's morphological pathology from cognitive impairment [PDF]

, 2009
We observed the Alzheimer's morphological pathology, amyloid production induces Alzheimer's cognitive impairment, was dissociated from the cognitive impairment.
Nobuyuki Mikoda, Tohru Hasegawa
core   +1 more source

Mixed Ionic and Electronic Charge Transport in Conductive Protein Fibers Revealed with DC Electrical Measurements

Advanced Materials, EarlyView.
M13 bacteriophage films deposited on micro interdigitated electrodes behave as a Randles simplified equivalent circuit under direct current. We derive contact and film resistance as well as capacitance of films of M13 phages, aromatic curli fibers or pilA‐containing nanowires.
Daniel Modafferi, Xinxin Hao, Kingsley L.‐J. Wong, Juliana Ferraro, Weijia Zhang, Oliver Xie, Noémie‐Manuelle Dorval Courchesne   +6 more
wiley   +1 more source