Results 121 to 130 of about 504,545 (312)

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

Duodenum amyloid deposition

, 2005
Duodenum with amyloid deposition in lamina propria. Amyloid etiology unknown.

core  

A primer of amyloid nomenclature

, 2007
The increasing knowledge of the exact biochemical nature of the localized and systemic amyloid disorders has made a logical and easily understood nomenclature absolutely necessary. Such a nomenclature, biochemically based, has been used for several years
Frangione, Blas, Ikeda, Shu-Ichi, Saraiva, Maria J., Buxbaum, Joel N., Cohen, Alan S., Masters, Colin L., Merlini, Giampaolo, Sipe, Jean D., Benson, Merrill D., Westermark, Per,   +9 more
core   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Monitoring patients and asymptomatic carriers with hereditary transthyretin amyloidosis: regional protocol of Emilia-Romagna ATTR working group

Frontiers in Neurology
Transthyretin amyloidosis (ATTR) is a rare disease caused by the extracellular accumulation of misfolded transthyretin (TTR) amyloid fibrils. ATTR can be either hereditary (ATTRv) or acquired (wtATTR).
Pietro Guaraldi, Isabella Allegri, Alessandra Ariatti, Tommaso Baldini, Andrea Barbieri, Federico Barocelli, Michela Bartolotti, Elena Biagini, Elena Biagini, Francesca Bianchi, Annamaria Borghi, Claudia Borghi, Giuseppe Boriani, Ilaria Cani, Samuela Carigi, Luca Codeluppi, Marco Currò Dossi, Francesca Dalpozzo, Roberto D’Angelo, Riccardo De Gennaro, Francesco Di Spigno, Elisa Gardini, Gianluca Lanati, Chiara Leuzzi, Francesca Marzo, Marco Masullo, Gaia Mazzanti, Elisa Merli, Agnese Milandri, Dennis Monari, Enrica Perugini, Alberto Ponziani, Alberto Ponziani, Emanuela Postiglione, Marta Rasia, Rita Rinaldi, Davide Scancarello, Kevin Serafini, Matteo Serenelli, Maurizio Sguazzotti, Ernesto Siena, Anna Maria Simone, Chiara Terracciano, Chiara Valenti, Giovanni Vitale, Maria Vitiello, Simone Longhi   +46 more
doaj   +1 more source

A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology

, 2015
We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).
Cummings, DM, Moens, TG, Fulleylove, M, Liu, W, Latcham, J, Smith, KJ, NahabooSolim, MA, Edwards, FA, Desai, R, Ali, SS, Matarin, M, Paublete, RM, Perona, M, Salih, DA, Guelfi, S, Richardson, JC, Yasvoina, M, Hardy, J   +17 more
core  

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

Advanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan, Peng Li, Yue Wang, Xin Qi, Wanyu Wang, Yongzhong Cheng, Huabin Zhang, Xin Hu, Xiang Gao   +8 more
wiley   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

The Cognitive Changes Among Patients over 65 Years of Age in a Rural Area—The Preliminary Report of Protective and Predisposing Factors

Neurology International
Background: Aβ1-42 and APOE concentrations, as well as Aβ42/40 ratio, may be considered as a link between hypertension (HTN) or diabetes mellitus (DM), brain amyloidosis, and dementia.
Radoslaw Zachara, Daria Gendosz de Carrillo, Adam Wlaszczuk, Agnieszka Gorzkowska, Wiktoria Mazur, Halina Jedrzejowska-Szypulka   +5 more
doaj   +1 more source

Medin-amyloid : a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body

, 2005
Amyloid deposition occurs commonly in the aging aortic media. We recently found that a 50 amino acid amyloid fibril protein, which we called medin, forms the fibrils of this amyloid form.
Glennert, Johanna, Peng, Siwei,, Westermark, Per,   +2 more
core   +1 more source