Results 131 to 140 of about 504,545 (312)

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

The Link Between Physical Function, β-Amyloid, and Cognitive Aging in Women

Applied Sciences
This study aimed to examine associations between functional capacity (FC), brain β-amyloid (Aβ) burden, and longitudinal cognitive performance. Data from 89 cognitively normal women (70.0 ± 2.7 years) in the Women’s Healthy Ageing Project cohort were ...
Raquel Pedrero-Chamizo, Cassandra Szoeke
doaj   +1 more source

Association of cerebral amyloid-\u3b2 aggregation with cognitive functioning in persons without dementia

, 2018
: Importance Cerebral amyloid-\u3b2 aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the ...
Zboch, Marzena, de Oliveira, Catarina Resende, Engelborghs, Sebastiaan, Landau, Susan M., Tijms, Betty M., Fleisher, Adam S., Mintun, Mark A., Kornhuber, Johannes, Hansson, Oskar, Mok, Vincent, Gabryelewicz, Tomasz, Sabri, Osama, Kramberger, Milica G., Froelich, Lutz, Frisoni, Giovanni B., Drzezga, Alexander, Madsen, Karine, Jagust, William J., Mroczko, Barbara, Verhey, Frans R. J., Mattsson, Niklas, Sanchez-Juan, Pascual, Verbeek, Marcel M., Visser, Pieter Jelle, Parnetti, Lucilla, Fagan, Anne M., Popp, Julius, Vandenberghe, Rik, Camus, Vincent, Rowe, Christopher C., Ossenkoppele, Rik, Wolk, David A., Rinne, Juha O., Jansen, Willemijn J., Lleo, Alberto, Rabinovici, Gil D., Klunk, William E., Wallin, Anders, Brooks, David J., Ivanoiu, Adrian, Fladby, Tormod, Chetelat, Gael, Meyer, Philipp T., Na, Duk L., Villemagne, Victor L., Tsolaki, Magda, Aalten, Pauline, Kapaki, Elisabeth, Newberg, Andrew, Lee, Dong Young, Molinuevo, Jose Luis, de Mendonca, Alexandre, van der Flier, Wiesje M., Nordberg, Agneta, Sarazin, Marie, Hildebrandt, Helmut, Scheltens, Philip   +56 more
core  

Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid

, 2016
Amyloidosis is a protein conformational disorder in which amyloid fibrils accumulate in the extracellular space and induce organ dysfunction. Recently, two different amyloidogenic proteins, transthyretin (TTR) and apolipoprotein A-I (Apo A-I), were ...
Misumi, Yohei,, Yanagisawa, Akihiro,, Ueda, Mitsuharu,, Motokawa, Hiroaki,, Kinoshita, Yumiko,, Toyoshima, Risa,, Suenaga, Genki,, Mizuta, Hiroshi,, Westermark, Per,, Sakaguchi, Mitsuru,, Tasaki, Masayoshi,, Ando, Yukio,, Yamashita, Taro,, Nakamura, Eiichi,, Sueyoshi, Takanao,   +14 more
core   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Enhanced in vitro production of amyloid-like fibrils from mutant (S20G) islet amyloid polypeptide

, 2001
Islet amyloid polypeptide (IAPP, "amylin") is the amyloid-fibril-forming polypeptide in the islets of Langerhans associated with type 2 diabetes mellitus.
Nanjo, K, Gustavsson, Å, Sanke, T, Westermark, GT, Sakagashira, S, Westermark, P,, Engström, Ulla,, Ma, Z, Sakamoto, H   +8 more
core  

Establishing the fluorescent amyloid ligand h-FTAA for studying human tissues with systemic and localized amyloid

, 2016
Rapid and accurate detection of amyloid deposits in routine surgical pathology settings are of great importance. The use of fluorescence microscopy in combination with appropriate amyloid specific dyes is very promising in this regard.
Nilsson, Peter,, Westermark, Gunilla T.,, Hammarström, Per,, Nilsson, K. Peter R.,, Roecken, Christoph,, Sjölander, Daniel,, Westermark, Per,   +6 more
core   +1 more source