Results 131 to 140 of about 405,002 (265)

Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants. [PDF]

Acta Neuropathol
Fancy NN, Willumsen N, Chau VMN, Boulger SL, Whitwell HJ, Wang W, Avot B, Thomas M, Talbot-Martin J, Tsartsalis S, Khozoie C, McGarry A, Schneegans E, Yagoubi R, Cheung TKD, Papageorgopoulou M, Adair E, Cooper B, Davey K, Smith AM, Scotton W, Hardy J, Matthews PM, Jackson JS.   +23 more
europepmc   +1 more source

Amyloid Imaging [PDF]

Journal of Nuclear Medicine Technology, 2018
openaire   +2 more sources

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

An ABC of Amyloid [PDF]

Proceedings of the Royal Society of Medicine, 1973
openaire   +2 more sources

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Blood-based proteomic signature of amyloidosis: identification of novel regulators of amyloid load. [PDF]

Alzheimers Dement
Chen Y, Duggan MR, Timsina J, Xu Y, Western D, Gong K, Liu M, Budde J, Schindler SE, Morris JC, Holtzman DM, Benzinger TLS, Gordon BA, Moqri M, Knight Alzheimer Disease Research Center (Knight‐ADRC), Ibanez L, Walker KA, Cruchaga C, Ali M.   +18 more
europepmc   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Imaging and plasma biomarkers for pathological accumulation in Down syndrome. [PDF]

Brain
Wisch JK, Jiao Z, Kennedy JT, Cohen AD, Schlachetzki Z, Petersen M, Handen BL, Christian BT, Mapstone M, Rosas HD, Lai F, Lee JH, Krinsky-McHale SJ, Schmitt FA, Harp JP, Hom C, Lott IT, Hartley S, Zaman S, Ptomey L, Burns JM, Tudorascu D, Ibanez L, Rafii MS, Head E, Ances BM.   +25 more
europepmc   +1 more source

Amyloid Cardiomyopathy ∗

Journal of the American College of Cardiology, 2016
Merrill D, Benson, Noel R, Dasgupta
openaire   +2 more sources

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source