Results 101 to 110 of about 504,545 (312)

Genome-Wide Association Study Identifies Two Novel Regions at 11p15.5-p13 and 1p31 with Major Impact on Acute-Phase Serum Amyloid A [PDF]

, 2010
Elevated levels of acute-phase serum amyloid A (A-SAA) cause amyloidosis and are a risk factor for atherosclerosis and its clinical complications, type 2 diabetes, as well as various malignancies.
Illig, T, Spector Tim D., Kleber, M.E., März Winfried, Wichmann, H. -Erich, Mangino, M, Waldenberger, M, Hammond Christopher J., Prokopenko, I, Hammond, Christopher J., Blackburn Hannah, Prokisch Holger, Winkelmann Bernhard R., Mangino, M., H.-Erich Wichmann, Kovacs, P., Wichmann, H.-E., Marzi, C, Illig, T., Waldenberger, Melanie, Tim D Spector, Geistlinger, Ludwig, Tönjes, A, Koenig Wolfgang, Peters, Annette, Thorand, Barbara, Illig Thomas, Boehm, Bernhard O., Toenjes, Anke, Peters Annette, Boehm Bernhard O., Hysi, P.G., Kovacs, Peter, Prokisch, H., Mangino Massimo, Marcus E Kleber, Annette Peters, Prokopenko, I., Pirro G. Hysi, Soranzo, Nicole, Christopher J. Hammond, Hysi, Pirro G., Koenig, W, Tönjes Anke, Hammond, C.J., Heim, K., Harald Grallert, H-Erich Wichmann, Bernhard O. Boehm, Marzi, C., Koenig, W., Gieger, Christian, Eva Albrecht, Soranzo, N, Hammond, CJ, Albrecht Eva, Hysi Pirro G., Vasiliki Lagou, Grallert, H., Koenig, Wolfgang, Nicole Soranzo, Spector, Tim D., Gieger, C, Marz, W., Melanie Waldenberger, Michael Stumvoll, Thorand Barbara, Hysi, PG, Boehm, BO, Carola Marzi, Boehm, B.O., Janina S Ried, Lagou, Vasiliki, Wichmann, Heinz-Erich, Bernhard R. Winkelmann, Inga Prokopenko, Hannah Blackburn, Heim, Katharina, Kleber, ME, Peters, A, Stumvoll, M, Anke Tönjes, März, W, Gieger, C., Ried, Janina S., Christian Gieger, Ried, JS, Bernhard O Boehm, Albrecht, E, Blackburn, H, Stumvoll, M., Pirro G Hysi, Lagou Vasiliki, Ried Janina S., Waldenberger Melanie, Thorand, B, Christopher J Hammond, Lagou, V, Gieger Christian, Blackburn, Hannah, Grallert, Harald, Heim, K, Kleber Marcus E., Prokopenko Inga, Spector, T.D., Marzi, Carola, Waldenberger, M., Winkelmann, B.R., Heim Katharina, Wichmann H.-Erich, Kleber, Marcus E., Wolfgang Koenig, Barbara Thorand, Tönjes, A., Soranzo, N., Winfried März, Prokisch, Holger, Stumvoll, Michael, Marcus E. Kleber, Tim D. Spector, Mangino, Massimo, Stumvoll Michael, Grallert, H, Wichmann, HE, Geistlinger, L, Peters, A., Illig, Thomas, Maerz, Winfried, Ried, J.S., Grallert Harald, Thomas Illig, Albrecht, Eva, Lagou, V., Bernhard R Winkelmann, Kovacs Peter, Geistlinger Ludwig, Kovacs, P, Prokisch, H, Prokopenko, Inga, Katharina Heim, Marzi Carola, Soranzo Nicole, Massimo Mangino, Ludwig Geistlinger, Geistlinger, L., Blackburn, H., Peter Kovacs, Spector, TD, Janina S. Ried, Albrecht, E., Thorand, B., Winkelmann, BR, Winkelmann, Bernhard R., Holger Prokisch   +153 more
core   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

Frontiers in Neuroscience, 2018
Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases in the US alone (Alzheimer's Association, 2016). Clinically, AD is defined by the presence of plaques composed of Aβ and neurofibrillary pathology composed of the ...
Erin E. Congdon
doaj   +1 more source

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Chiral Microneedle Arrays With Terahertz Chiroptical Activity With Chiral‐Plasmon‐Chiral‐Phonon Resonance

Advanced Materials, EarlyView.
ABSTRACT Microneedle arrays (MNAs) is a rapidly emerging technology with broad biomedical applications in drug delivery and biosensing. With sub‐millimeter dimensions and periodicity, MNAs possess geometries nearly ideal for biomedical devices operating within the terahertz (THz) spectral window.
Sang Hyun Lee, Hong Ju Jung, John Kim, Bum Chul Park, Caio V. C. R. da Silva, André F. de Moura, Nicholas A. Kotov   +6 more
wiley   +1 more source

Uptake of 18F-AV45 in the Putamen Provides Additional Insights into Alzheimer’s Disease beyond the Cortex

Biomolecules
Cortical uptake in brain amyloid positron emission tomography (PET) is increasingly used for the biological diagnosis of Alzheimer’s disease (AD); however, the clinical and biological relevance of the striatum beyond the cortex in amyloid PET scans ...
Zhengshi Yang, Jefferson W. Kinney, Dietmar Cordes, The Alzheimer’s Disease Neuroimaging Initiative   +3 more
doaj   +1 more source

Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]

, 2012
Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
core  

E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure

Advanced Materials, EarlyView.
The complex composite‐like mechanical behavior of E. coli biofilm matrix is the result of a synergic contribution of the rigid curli and swelling pEtN‐cellulose, and emerges from specific ratio and assembly conditions. The interactions between the two fibers govern biofilm hydration and characteristic wrinkling patterns, providing crucial insights for ...
Macarena Siri, Agustín Mangiarotti, Anne Seewald, Nikolai Rosenthal, Shahrouz Amini, Emeline Raguin, Peter Fratzl, Cécile M. Bidan   +7 more
wiley   +1 more source