Results 101 to 110 of about 547,277 (291)
Advanced Healthcare Materials, EarlyView.Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave +8 more
wiley +1 more source
Amyloid and inflammation [PDF]
Proceedings of the National Academy of Sciences, 2013 Thirty human and 10 animal proteins form amyloid fibrils associated with codeposition of P-component (SAP), heparatan sulfate proteoglycans (HSPGs), certain apolipoproteins (e.g., ApoE), as well as other less well-defined “ground substances” that may mitigate fibrillogenesis and tissue-specific deposition in association with aging or disease.
openaire +2 more sources
Optical Detection of Cellular Signals at Material Interfaces
Advanced Healthcare Materials, EarlyView.Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren +5 more
wiley +1 more source
All‐Amyloid Functional Coacervates
Advanced Materials, EarlyView.This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi +4 more
wiley +1 more source
BiomoleculesCortical uptake in brain amyloid positron emission tomography (PET) is increasingly used for the biological diagnosis of Alzheimer’s disease (AD); however, the clinical and biological relevance of the striatum beyond the cortex in amyloid PET scans ...
Zhengshi Yang +3 more
doaj +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
International Journal of Nanomedicine, 2010 Sun-Ho Han1, Yu Jin Chang1, Eun Sun Jung1, Jong-Won Kim2, Duk Lyul Na3, Inhee Mook-Jung11Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Jongro-gu, Seoul, Korea; 2Department of Laboratory Medicine and ...
Sun-Ho Han +3 more
doaj
Functionalized Titanium Implants Coated With Protein Nanofilms.
International Dental JournalAim or purpose: To develop surface coatings for Titanium implants and abutments using lactalbumin’s biological properties, leveraging controlled protein aggregation and interfacial adhesion to enhance soft tissue sealing, osteointegration, and ...
Yanyuan Zhang
doaj +1 more source