Results 171 to 180 of about 514,761 (295)
Advanced Science, EarlyView.Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang +7 more
wiley +1 more source
Considerably Unfolded Transthyretin Monomers Preceed and Exchange with Dynamically Structured Amyloid Protofibrils [PDF]
, 2015 Minna Groenning +4 more
openalex +1 more source
ATP Hydrolysis by α‐Synuclein Amyloids is Mediated by Enclosing β‐Strand
Advanced Science, EarlyView.Pathological amyloids have been considered chemically inert until recently. Here it is shown that α‐synuclein amyloids catalyze the hydrolysis of the universal energy molecule, ATP. The cryo‐EM structure of the complex reveals an additional β‐strand (purple) that encloses the ATP‐binding site. Within the cavity, several lysine residues are required for
Lukas Frey +6 more
wiley +1 more source
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide [PDF]
Bing Li +5 more
openalex +1 more source
Amyloid Precursor Proteins Interact with the Heterotrimeric G Protein Go in the Control of Neuronal Migration [PDF]
, 2013 Jenna M. Ramaker +2 more
openalex +1 more source
Active Learning‐Assisted Exploration of [PO40Mo12]3− for Alzheimer's Therapy Insights
Advanced Science, EarlyView.Bayesian Optimization coupled with active learning to uncover the interaction mechanism of [PO40Mo12]3− on amyloid‐β peptide. Abstract Alzheimer's disease (AD), involving amyloid‐β (Aβ) aggregation, has potential therapeutic modulators in polyoxometalates (POMs) like [PMo12O40]3−.
Lincan Fang +3 more
wiley +1 more source
Advanced Science, EarlyView.Antimicrobial peptides (AMPs) show potential as alternatives to antibiotics for bacterial infections; however, their susceptibility to proteases limits wider application. In this study, N4 nanofibers are constructed by integrating anti‐enzymolysis motif into the self‐assembly system triggered by naphthyl‐anchored.
Xi Yan +6 more
wiley +1 more source
Herpes simplex virus interferes with amyloid precursor protein processing [PDF]
, 2005 Suzanne J. Shipley +3 more
openalex +1 more source
Advanced Science, EarlyView.This work presents an automated and accessible point‐of‐care device, MEMOs, for the detection of exosomal Aβ42 protein, a potential blood biomarker for Alzheimer’s disease. MEMOs, with its automated operation workflow, minimizes hands‐on time and maintains high sensitivity in diagnosing AD, allowing non‐specialists to conduct tests at home and offering
Xiaoxue Fan +10 more
wiley +1 more source