Results 261 to 270 of about 514,761 (295)

Zebrafish: A Versatile and Powerful Model for Biomedical Research

BioEssays, EarlyView.
Zebrafish are vital for advancing precision medicine, offering a genetically tractable and optically transparent vertebrate model with strong genetic homology to humans. They enable rapid and cost‐effective disease modeling and drug discovery, accelerating insights into cardiovascular, neurological, metabolic, and oncological disorders through gene ...
Sundus Siddiqui, Hiba Siddiqui, Emna Riguene, Michail Nomikos   +3 more
wiley   +1 more source

TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?

BioEssays, EarlyView.
TDP‐43 hyperphosphorylation occurs in neurodegenerative diseases, however, it is not a driver of TDP‐43 aggregation, but enhances TDP‐43 solubility, suggesting that TDP‐43 hyperphosphorylation is protective. Toxicity may arise from a broader phosphorylation‐driven cellular pathway disruption.
Simone Mosna, Dorothee Dormann
wiley   +1 more source

Gold Nanoparticles Coated With Hydrophobin‐ProteinA Fusion Protein: Development of a Versatile Immunosensing Platform

Biotechnology and Bioengineering, EarlyView.
The biosensor uses a two‐step method involving Ab‐Vmh2/SpA‐AuNPs. Gold nanoparticles are functionalized with Vmh2/SpA, antibodies and then mixed with analytes. HCl induces aggregation in unbound particles enabling detection through spectral analysis based on analyte interaction and nanoparticle aggregation behavior.
Paola Cicatiello, Bartolomeo Della Ventura, Giulia Fichera, Raffaele Velotta, Paola Giardina, Alessandra Piscitelli   +5 more
wiley   +1 more source

Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future

Signal Transduction and Targeted Therapy, 2023
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer’s disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer’s pathogenesis and progression.
Weihong Song
exaly   +2 more sources

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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Nature Reviews Drug Discovery, 2022
Eric Karran, Bart De Strooper
exaly   +2 more sources

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Nature, 2002
Dominic M Walsh, Michael S Wolfe
exaly   +2 more sources

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Nature Reviews Molecular Cell Biology, 2007
C. Haass, D. Selkoe
exaly   +2 more sources

Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

Annual Review of Biochemistry, 2017
Fabrizio Chiti, Christopher M Dobson
exaly   +2 more sources

A new era for understanding amyloid structures and disease

Nature Reviews Molecular Cell Biology, 2018
Matthew G Iadanza, Eric W Hewitt, Neil A Ranson   +2 more
exaly   +2 more sources

Amyloid

Arthritis & Rheumatism, 2023
J. Piérard, A. Kint
semanticscholar   +1 more source