Results 341 to 350 of about 516,976 (376)
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Nature Neuroscience, 2011
The sustained metabolic activation of the brain's default-mode network is thought to render the system vulnerable to Alzheimer's disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.
Walker, Lary C, Jucker, Mathias
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The sustained metabolic activation of the brain's default-mode network is thought to render the system vulnerable to Alzheimer's disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.
Walker, Lary C, Jucker, Mathias
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Seminars in Respiratory and Critical Care Medicine, 2020
AbstractAmyloidosis is the term given to abnormal deposition of misfolded precursor proteins at single or multiple sites, leading to organ dysfunction or clinical signs and symptoms. Pulmonary manifestations are nonspecific and may be associated with several amyloid protein subtypes, commonly AL (light chain) and AA (autoimmune) amyloids.
Misbah Baqir, Teng Moua, Anja C. Roden
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AbstractAmyloidosis is the term given to abnormal deposition of misfolded precursor proteins at single or multiple sites, leading to organ dysfunction or clinical signs and symptoms. Pulmonary manifestations are nonspecific and may be associated with several amyloid protein subtypes, commonly AL (light chain) and AA (autoimmune) amyloids.
Misbah Baqir, Teng Moua, Anja C. Roden
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Amyloid fibril protein in familial amyloid polyneuropathy [PDF]
Neurology, 1981 Amyloid fibril protein was purified from organs of patients with familial amyloid polyneuropathy (Nagano prefecture, Japan). When compared with amyloid fibril protein from primary amyloidosis and secondary amyloidosis, the protein from familial amyloid polyneuropathy was shown to differ in the molecular weight of the subunit.
Shin'ichi Shoji, Akira Okano
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2016
When proteins do not fold correctly, it can lead to very serious diseases. One such group of diseases is the amyloid diseases, of which Alzheimer’s disease (AD), Parkinson’s disease, and type 2 diabetes mellitus (T2DM) are members. The amyloid diseases are characterized by the aggregation of a specific protein into amyloid fibrils. During this process,
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When proteins do not fold correctly, it can lead to very serious diseases. One such group of diseases is the amyloid diseases, of which Alzheimer’s disease (AD), Parkinson’s disease, and type 2 diabetes mellitus (T2DM) are members. The amyloid diseases are characterized by the aggregation of a specific protein into amyloid fibrils. During this process,
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QJM: An International Journal of Medicine, 1974
Seven, cases of amyloid goitre are added to a review of this condition. In one case an iodinated protein of smaller molecular weight than thyroglobulin was recovered from the goitrous gland in addition to thyroglobulin. Autoradiography, however, showed no evidence that amyloid is iodinated.
J. S. Kennedy +2 more
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Seven, cases of amyloid goitre are added to a review of this condition. In one case an iodinated protein of smaller molecular weight than thyroglobulin was recovered from the goitrous gland in addition to thyroglobulin. Autoradiography, however, showed no evidence that amyloid is iodinated.
J. S. Kennedy +2 more
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Diseases of the Colon & Rectum, 1982
Amyloidosis not infrequently involves the gastrointestinal tract and may result in a variety of symptoms, including those related to impaired motility, malabsorption, and ulceration due to ischemia. This report describes the case of a 74-year-old man with systemic amyloidosis secondary to multiple myeloma, with striking gross morphologic findings ...
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Amyloidosis not infrequently involves the gastrointestinal tract and may result in a variety of symptoms, including those related to impaired motility, malabsorption, and ulceration due to ischemia. This report describes the case of a 74-year-old man with systemic amyloidosis secondary to multiple myeloma, with striking gross morphologic findings ...
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Journal of the American Academy of Dermatology, 1988
Cutaneous lesions are present in up to 40% of patients with primary and myeloma-associated systemic amyloidosis and occur as a result of tissue deposition of immunoglobulin light chain material derived from a circulating paraprotein. The occurrence of waxy, purpuric mucocutaneous lesions provides a crucial early pointer to underlying occult plasma cell
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Cutaneous lesions are present in up to 40% of patients with primary and myeloma-associated systemic amyloidosis and occur as a result of tissue deposition of immunoglobulin light chain material derived from a circulating paraprotein. The occurrence of waxy, purpuric mucocutaneous lesions provides a crucial early pointer to underlying occult plasma cell
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Gastrointestinal amyloid deposition in familial amyloid polyneuropathy
Neurology, 1982We found degeneration of enteric nerve plexuses in two patients with type I familial amyloid polyneuropathy. Amyloid deposition was more severe in the wall of the stomach than in the rectum. Hypomotility of the upper gastrointestinal tract, resulting from both amyloid deposition in the stomach and upper bowel and degeneration of the intrinsic autonomic
Shu-ichi Ikeda +4 more
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International Archives of Allergy and Immunology, 1968
J. Sri Ram, R.A. DeLellis, G.G. Glenner
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J. Sri Ram, R.A. DeLellis, G.G. Glenner
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics
Nature Reviews Drug Discovery, 2022Eric Karran +2 more
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