Results 71 to 80 of about 516,976 (376)

Depression screening in cognitively normal older adults: Measurement bias according to subjective memory decline, brain amyloid burden, cognitive function, and sex

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Understanding the associations among depression, subjective cognitive decline, and prodromal Alzheimer's disease (AD) has important implications for both depression and dementia screening in older adults. The Geriatric Depression Scale (GDS)
Louisa I. Thompson, Richard N. Jones
doaj   +1 more source

Insights into the variability of nucleated amyloid polymerization by a minimalistic model of stochastic protein assembly [PDF]

, 2015
Self-assembly of proteins into amyloid aggregates is an important biological phenomenon associated with human diseases such as Alzheimer's disease. Amyloid fibrils also have potential applications in nano-engineering of biomaterials. The kinetics of amyloid assembly show an exponential growth phase preceded by a lag phase, variable in duration as seen ...
arxiv   +1 more source

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction We examined the associations among instrumental activities of daily living (IADL), cortical amyloid, and cognition in cognitively normal (CN) older adults.
Gad A. Marshall, Sietske A. M. Sikkes, Rebecca E. Amariglio, Jennifer R. Gatchel, Dorene M. Rentz, Keith A. Johnson, Oliver Langford, Chung‐Kai Sun, Michael C. Donohue, Rema Raman, Paul S. Aisen, Reisa A. Sperling, Douglas R. Galasko, Full listing of A4 Study team and site personnel available at A4STUDY.org   +13 more
doaj   +1 more source

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Frontiers in Immunology, 2020
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau protein aggregates in neurons, are two pathological hallmarks of Alzheimer'
Junling Yang, Leslie Wise, Ken-ichiro Fukuchi   +2 more
doaj   +1 more source

Amyloid Formation by Globular Proteins: The Need to Narrow the Gap Between in Vitro and in Vivo Mechanisms

Frontiers in Molecular Biosciences, 2022
The globular to fibrillar transition of proteins represents a key pathogenic event in the development of amyloid diseases. Although systemic amyloidoses share the common characteristic of amyloid deposition in the extracellular matrix, they are ...
Giulia Faravelli, Valentina Mondani, P. Patrizia Mangione, P. Patrizia Mangione, Sara Raimondi, Loredana Marchese, Francesca Lavatelli, Monica Stoppini, Alessandra Corazza, Alessandra Corazza, Diana Canetti, Guglielmo Verona, Laura Obici, Graham W. Taylor, Julian D. Gillmore, Sofia Giorgetti, Sofia Giorgetti, Vittorio Bellotti, Vittorio Bellotti, Vittorio Bellotti, Vittorio Bellotti   +20 more
doaj   +1 more source

CSF sTREM2: Marking the tipping point between preclinical AD and dementia? [PDF]

, 2016
Biomarkers for Alzheimer's disease (AD) have improved our understanding of the temporal sequence of biological events that lead to AD dementia (Jack et al, 2013).
Holtzman, David M, Schindler, Suzanne E
core   +2 more sources

Prevalence, Characteristics, and Impact on Prognosis of Aortic Stenosis in Patients With Cardiac Amyloidosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiac amyloidosis (CA) is frequently found in older patients with aortic stenosis (AS). However, the prevalence of AS among patients with CA is unknown.
Mohamed‐Salah Annabi, Rasmus Carter‐Storch, Amira Zaroui, Arnault Galat, Silvia Oghina, Mounira Kharoubi, Mélanie Bezard, Geneviève Derumeaux, Pascale Fanen, François Lemonnier, Elsa Poullot, Emmanuel Itti, Romain Gallet, Emmanuel Teiger, Philippe Pibarot, Thibaud Damy, Marie‐Annick Clavel   +16 more
doaj   +1 more source

A novel canonical dual computational approach for prion AGAAAAGA amyloid fibril molecular modeling [PDF]

J Theor Biol 284 (1) 149-157 (2011); selected by Protein Crystallography Newsletter Volume 3, No. 9, September 2011, Crystallography Times; Prions Research Today Volume 7 Issue 7, July 2011, p.14; the 18th of the Top 25 Hottest Articles (picked up from papers of Jul 2011 to Sept 2011 of J Theor Biol), 2011
Many experimental studies have shown that the prion AGAAAAGA palindrome hydrophobic region (113-120) has amyloid fibril forming properties and plays an important role in prion diseases. However, due to the unstable, noncrystalline and insoluble nature of the amyloid fibril, to date structural information on AGAAAAGA region (113-120) has been very ...
arxiv   +1 more source

Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage [PDF]

, 2004
BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates.
Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Wilcock, Donna M   +6 more
core   +3 more sources