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Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers
Biochemical and Biophysical Research Communications, 2011Aggregation of a peptide, beta-amyloid (Aβ), is a hallmark molecular process found in Alzheimer's disease (AD). During Aβ aggregation, oligomeric and fibrillar Aβ are formed, and these molecular self-assembly steps are implicated in generation of toxic effects in AD.
Jin Ryoun Kim +3 more
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Amyloid Beta: The Alternate Hypothesis
Current Alzheimer Research, 2006Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the ...
Hyoung Gon Lee +4 more
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Clearance of Beta-Amyloid in the Brain
Current Medicinal Chemistry, 2014Intravascular substances invade extracellular spaces in the brain via endothelial cells in the sites without bloodbrain barrier (BBB) and move not only in the cerebrospinal fluid (CSF) but also in the interstitial fluid (ISF) of brain parenchyma adjacent to non-BBB sites.
Yoichi Chiba +4 more
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Neurodegenerative Diseases, 2007
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-β (Aβ), a peptide of 39–42 amino acids generated in vivo by specific, proteolytic cleavage of the ...
Rudi Glockshuber, Verena H. Finder
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Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. A hallmark of AD is the accumulation of plaques in the brain of AD patients. The plaques predominantly consist of aggregates of amyloid-β (Aβ), a peptide of 39–42 amino acids generated in vivo by specific, proteolytic cleavage of the ...
Rudi Glockshuber, Verena H. Finder
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Experimental Eye Research, 2009
Amyloid b (Ab) [P05067 Swiss-Prot], one of the proteins shown to be associated with the onset of Alzheimer’s disease (AD), commonly exits in three forms comprising of either 38, 40 or 42 amino acids (Walsh and Selkoe, 2007). Ab is produced via the amyloidogenic pathway through posttranslational cleavage of the membrane bound Ab precursor protein (APP ...
Eduardo M. Normando +3 more
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Amyloid b (Ab) [P05067 Swiss-Prot], one of the proteins shown to be associated with the onset of Alzheimer’s disease (AD), commonly exits in three forms comprising of either 38, 40 or 42 amino acids (Walsh and Selkoe, 2007). Ab is produced via the amyloidogenic pathway through posttranslational cleavage of the membrane bound Ab precursor protein (APP ...
Eduardo M. Normando +3 more
openaire +3 more sources
Amyloid beta antagonizes insulin promoted secretion of the amyloid beta protein precursor
Journal of Alzheimer's Disease, 2002Amyloid beta (Abeta) peptides are direct competitive inhibitors of insulin binding and action [25]. We demonstrate that Abeta peptides can inhibit the effect of insulin on the metabolic processing of the amyloid beta protein precursor (AbetaPP). As evidence emerges concerning the role of insulin and insulin like growth factors (IGFs) in learning and ...
Marco Racchi +4 more
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2019
Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons,
Abhinav Anand +3 more
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Alzheimer's disease (AD), exhibiting accumulation of amyloid beta (Aβ) peptide as a foremost protagonist, is one of the top five causes of deaths. It is a neurodegenerative disorder (ND) that causes a progressive decline in memory and cognitive abilities. It is characterized by deposition of Aβ plaques and neurofibrillary tangles (NFTs) in the neurons,
Abhinav Anand +3 more
openaire +1 more source