Results 341 to 350 of about 249,317 (377)

Cholesterol Trafficking and Amyloid Beta Peptides

Pharmacopsychiatry, 2003
Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the relationship between amyloid beta-peptide (Abeta) and cholesterol that can be described as a reciprocal process.
U Igbavboa, W G Wood
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Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
Tsunao Saitoh, Tilman Oltersdorf, David Schubert, Greg M. Cole   +3 more
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Current progress in beta-amyloid immunotherapy

Current Opinion in Immunology, 2004
As neuroscientists, we are taught that the brain is immune privileged and thus unlikely to be affected by the peripheral immune system. Accordingly, initial results demonstrating the effectiveness of beta-amyloid (Abeta) immunotherapy in mouse models of Alzheimer's disease (AD) were viewed with considerable surprise and some skepticism.
Peter Seubert, Dale Schenk, Michael Hagen   +2 more
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In Vivo Phagocytosis Analysis of Amyloid Beta

2019
Alzheimer's disease (AD) pathology is characterized by the presence of extracellular amyloid beta (Aβ), tau hyperphosphorylation, and neuroinflammation. One striking feature in the disease is the clustering of microglia around Aβ plaques. These cells exhibit a highly and chronically activated phenotype, performing a variety of functions, phagocytosis ...
Tejera, Darío, Heneka, Michael T.
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The role of amyloid-beta in the regulation of memory

Biochemical Pharmacology, 2014
In this review there is evidence that amyloid-beta peptide is a memory enhancer at physiological (picomolar) concentrations. Pathological overproduction of amyloid-beta leads to impaired memory, oxidative damage, damage to the blood brain barrier, neurofibrillary tangles and amyloid plaque formation.
John E. Morley, Susan A. Farr
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Beta-amyloid immunisation in Alzheimer’s disease

Neurological Sciences, 2005
Beta-amyloid immunisation in Alzheimer's ...
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Cholesterol, Lipids, Amyloid Beta, and Alzheimers

Current Alzheimer Research, 2010
High levels of cholesterol have been proposed as a risk factor for Alzheimer's disease (AD). Polymorphism of genes encoding proteins that regulate cholesterol metabolism have also been associated with the frequency of Alzheimer's development. Some studies have shown that cholesterol-lowering drugs reduce the frequency of AD development.
Masahiro Takagi, Tsutomu Hamada, Masamune Morita, Mun'delanji Vestergaard   +3 more
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Beta-amyloid and cholinergic neurons.

Neurochemical research, 2003
It is generally accepted that the crucial events in the pathogeny of Alzheimer's disease (AD) are the increased accumulation of amyloidogenic peptides derived from amyloid precursor protein and the harmful actions of these peptides on neurons, which bring about neurodegeneration. The enhanced beta-amyloid accumulation is known to be caused by mutations
Kasparová J, Dolezal
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Neprilysin and Amyloid Beta Peptide Degradation

Current Alzheimer Research, 2008
Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B. Hersh, David W. Rodgers
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Amyloid Beta and the Cerebral Vasculature [PDF]

, 2005
The vascular pattern of amyloid beta (Aβ) deposition in the brain is commonly referred to as cerebral amyloid angiopathy (CAA) (1). CAA is an important cause of cerebral hemorrhages and may lead to ischemic infarction and dementia (2). A pure form of CAA, without parenchymal lesions, has been documented in hereditary cerebral hemorrhage, Dutch type ...
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