Results 111 to 120 of about 384,012 (260)

Genetic and Clinical Spectrum of Hereditary Transthyretin Amyloidosis in Brazil

Journal of the Peripheral Nervous System, Volume 31, Issue 1, March 2026.
ABSTRACT Background Transthyretin hereditary amyloidosis (ATTRv) clinical variability has been widely reported, not only across countries and variants but also among families and distinct regions within a single nation. One of the principal challenges in disease management is the accurate determination of age of onset (AOO), which is heterogeneous and ...
Gustavo Maximiano‐Alves, Carolina Lavigne‐Moreira, Marcus Vinicius Simões, Adilson Junior Pinto Galvão, Flavio Henrique Valicelli, Fernando Saraiva Coneglian, Elisa Vegezzi, Pedro Manoel Marques Garibaldi, Pedro José Tomaselli, Andrea Cortese, Wilson Marques Jr   +10 more
wiley   +1 more source

Prevalence of Isolated Atrial Amyloidosis in Young Patients Affected by Congestive Heart Failure

The Scientific World Journal, 2012
Atrial natriuretic peptide (ANP), whose amyloid is responsible of isolated atrial amyloidosis (IAA), is known to play an important role in the pathophysiology of congestive heart failure (CHF).
Lia Millucci, Lorenzo Ghezzi, Giulia Bernardini, Daniela Braconi, Piero Tanganelli, Annalisa Santucci   +5 more
doaj   +1 more source

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Gallimore, JR, Gilbertson, JA, Gillmore, JD, Goodman, HJB, Hawkins, PN, Lachmann, HJ, Sabin, CA   +6 more
core   +1 more source

Amyloid Cardiomyopathy: All that sparkles is Amyloid

International Cardiovascular Forum Journal, 2016
A 73 year old female with no past medical history presented to our emergency department (ED) with gradually worsening shortness of breath for a few weeks. She denied any associated complaints of chest pain, palpitations or dizziness. On physical exam, the patient had bilateral rales at the lung bases.
Abhinav Saxena, Sameer Chadha, On Chen, Adnan Sadiq, Jacob Shani   +4 more
openaire   +1 more source

Clinical and Prognostic Implications of Right Ventricular Uptake on Bone Scintigraphy in Transthyretin Amyloid Cardiomyopathy

Circulation
BACKGROUND: The extent of myocardial bone tracer uptake with technetium pyrophosphate, hydroxymethylene diphosphonate, and 3,3-diphosphono-1,2-propanodicarboxylate in transthyretin amyloid cardiomyopathy (ATTR-CM) might reflect cardiac amyloid burden and
A. Porcari, M. Fontana, M. Canepa, E. Biagini, F. Cappelli, C. Gagliardi, S. Longhi, L. Pagura, G. Tini, F. Dore, R. Bonfiglioli, Matteo Bauckneht, A. Miceli, Francesca Girardi, Anna Lisa Martini, G. Barbati, E. N. Costanzo, A. Caponetti, A. Paccagnella, M. Sguazzotti, Giovanni La Malfa, M. Zampieri, R. Sciagrà, F. Perfetto, D. Rowczenio, J. Gilbertson, D. Hutt, P. Hawkins, C. Rapezzi, M. Merlo, G. Sinagra, J. Gillmore   +31 more
semanticscholar   +1 more source

Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. [PDF]

, 2018
Aging is a complex process strongly determined by genetics. Previous reports have shown that the genome of neuronal cells displays somatic genomic mosaicism including DNA copy number variations (CNVs).
Grinberg, Lea T, Leite, Renata, Pasqualucci, Carlos Augusto, Pearson, Peter, Rosenberg, Carla, Suemoto, Claudia K, Suemoto, Claudia K, Villela, Darine   +7 more
core   +1 more source

Molecular mechanisms and emerging therapies in wild-type transthyretin amyloid cardiomyopathy

Heart Failure Reviews
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin (TTRwt) myocardial deposition.
Danni Wu, Wei Chen
semanticscholar   +1 more source

The role of fibrocytes in fibrotic diseases of the lungs and heart [PDF]

, 2011
Fibrosis is the end result of a complex series of events that follow tissue injury and inflammation. Pathophysiologic fibrosis results in permanent scar formation, and can impair organ function.
Ellen C Keeley, Borna Mehrad, Robert M Strieter   +2 more
core   +1 more source

Senile Systemic Amyloidosis: An Underdiagnosed Disease [PDF]

, 2017
Senile systemic amyloidosis is caused by a non-mutated form of transthyretin with the heart being the major organ involved. This infiltrative cardiomyopathy usually presents as slowly progressive heart failure.
Domingos, Raquel, Manso, Marta Catarino, Paixão Marques, Diogo, Rocha, Sara L., Rodeia, Simão C.   +4 more
core   +3 more sources

Impact of tafamidis on myocardial function and CMR tissue characteristics in transthyretin amyloid cardiomyopathy

ESC Heart Failure
Tafamidis improves clinical outcomes in transthyretin amyloid cardiomyopathy (ATTR‐CM), yet how tafamidis affects cardiac structure and function remains poorly described.
S. Dobner, B. Bernhard, Lorenz Ninck, Monika Wieser, A. Bakula, Andreas Wahl, Valentin Köchli, G. Spano, Martina Boscolo Berto, E. Elchinova, Y. Safarkhanlo, Stefan Stortecky, Jonathan Schütze, I. Shiri, L. Hunziker, Christoph Gräni   +15 more
semanticscholar   +1 more source