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Heart, Lung and Circulation, 2020
Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
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Amyloid cardiomyopathy is emerging as an important and under-recognised cause of heart failure and cardiac arrhythmias, especially in older adults. This disorder is characterised by extracellular deposition of amyloid fibrils that form due to misfolding of secreted light chains (AL) or transthyretin protein (ATTR). In ATTR, amyloid aggregates typically
Nicole K. Bart +5 more
openaire +7 more sources
Transthyretin amyloid cardiomyopathy
The American Journal of the Medical Sciences, 2023Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed cause of heart failure and arrhythmia. This differential diagnosis should particularly be considered in older patients with left ventricular hypertrophy (LVH) who are also suffering from heart failure with preserved ejection fraction (HFpEF) or aortic valve stenosis.
Giuseppe, Famularo, Guido, Ventroni
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Transthyretin amyloid cardiomyopathy
Medicina Clínica (English Edition), 2021Transthyretin (TTR) cardiac amyloidosis is a severe, progressive, infiltrative disease caused by the deposition of TTR at cardiac level. It may be due to a genetic alteration in its hereditary form (ATTRv) or as a consequence of an age-related degenerative process (ATTRwt). Thanks to advances in imaging techniques and the possibility of achieving a non-
Pablo, Garcia-Pavia +2 more
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Clinical management of amyloid cardiomyopathy
Heart Failure Reviews, 2021Clinical heart failure, restrictive cardiomyopathy, and arrhythmias are hallmark features of amyloid cardiomyopathy. In contrast to the advancements in targeted therapies, there is a general lack of evidence-based practice guidelines for clinical management of amyloid cardiomyopathy.
Morris M. Kim +3 more
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Fulminant Amyloid Cardiomyopathy
Cardiology, 2008Within a 3-month period, a 71-year-old man went from an asymptomatic, active existence to intractable heart failure and death. Widespread amyloid deposition was noted on the histologic examination of endomyocardial biopsy samples. The historical and laboratory features of this patient’s rapidly devastating clinical course form the basis of this report.
B J, Donelan +3 more
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Amyloid Cardiomyopathy in the Emergency Department
Journal of Emergency Medicine, 2019Cardiac amyloidosis is an underdiagnosed cause of restrictive cardiomyopathy resulting from the infiltration of the myocardium by amyloid proteins.We report the case of an 83-year-old woman who presented with increasing dyspnea and lower-extremity swelling. She reported a medical history of unspecified heart failure.
Mauricio Baca
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Tafamidis for Transthyretin Amyloid Cardiomyopathy
New England Journal of Medicine, 2019Abstract not ...
Maurer, Mathew S +2 more
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Newer Therapies for Amyloid Cardiomyopathy
Current Heart Failure Reports, 2016The heart and the kidneys are the most commonly involved organs in systemic amyloidosis. Cardiac involvement is associated with an increased morbidity, treatment intolerance, and poorer overall survival. The most common types of amyloidosis that are associated with cardiac involvement include light chain (AL) amyloidosis and transthyretin (TTR ...
Rajshekhar, Chakraborty +2 more
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