A review of transthyretin cardiac amyloidosis
Romanian Journal of Internal Medicine, 2023 Transthyretin cardiac amyloidosis is a progressive disease known to cause heart failure, conduction anomalies, and arrythmias. Due to poor outcomes and mortality from severe cardiomyopathy, prevalence and incident rates are often underreported. As global
Jhawar Nikita +2 more
doaj +1 more source
Ser77Tyr transthyretin amyloidosis in Israel: Initial manifestations and diagnostic features
Annals of Clinical and Translational Neurology, 2023 Objective Amyloidosis due to the transthyretin Ser77Tyr mutation (ATTRS77Y) is a rare autosomal‐dominant disorder, characterized by carpal‐tunnel syndrome, poly‐ and autonomic‐neuropathy, and cardiomyopathy.
Amir Dori +15 more
doaj +1 more source
Comparison of T1 mapping techniques for ECV quantification. histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR [PDF]
, 2012 BACKGROUND: Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium.
A. S. Flett +9 more
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Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy
New England Journal of Medicine, 2018 Background Transthyretin amyloid cardiomyopathy is caused by the deposition of transthyretin amyloid fibrils in the myocardium. The deposition occurs when wild‐type or variant transthyretin becomes unstable and misfolds. Tafamidis binds to transthyretin,
M. Maurer +21 more
semanticscholar +1 more source
ESC Heart Failure, 2022 While 99mTc‐pyrophosphate scintigraphy is clearly useful in diagnosing transthyretin amyloid cardiomyopathy (ATTR‐CM), it is necessary to know the pitfalls of this test for proper use. We present a rare case of concurrent ATTR‐CM and amyloid light chain (
Hidenori Moriyama +8 more
doaj +1 more source
Mitochondrial Dysfunction in Aging and Diseases of Aging. [PDF]
, 2019 Mitochondria have been increasingly recognized as the important players in the aging process [...]
Haas, Richard H
core +2 more sources
Left ventricular active strain energy density is a promising new measure of systolic function
Scientific Reports, 2022 The left ventricular ejection fraction does not accurately predict exercise capacity or symptom severity and has a limited role in predicting prognosis in heart failure.
David H. MacIver +3 more
doaj +1 more source
AMYLOID CARDIOMYOPATHY: DIAGNOSIS AND TREATMENT
Байкальский медицинский журнал, 2023 The review presents current data on heart disease in systemic amyloidosis. The article discusses variants of amyloi-dosis with common heart disease: AL-, ATTRwt- and ATTRv amyloidoses.
Elena S Eniseeva
doaj +1 more source
Observational Study Design in Veterinary Pathology, Part 1: Study Design [PDF]
, 2018 Observational studies are the basis for much of our knowledge of veterinary pathology and are highly relevant to the daily practice of pathology. However, recommendations for conducting pathology-based observational studies are not readily available.
Amanda P. Beck +22 more
core +6 more sources
Uncovering the Mechanism of Aggregation of Human Transthyretin. [PDF]
, 2015 The tetrameric thyroxine transport protein transthyretin (TTR) forms amyloid fibrils upon dissociation and monomer unfolding. The aggregation of transthyretin has been reported as the cause of the life-threatening transthyretin amyloidosis.
Cascio, Duilio +9 more
core +2 more sources