Results 71 to 80 of about 384,012 (260)

Systemic amyloidosis with predominant cardiac involvement associated with multiple myeloma

Медицинский вестник Юга России
A clinical case of amyloid cardiomyopathy associated with multiple myeloma with the development of chronic heart failure with preserved ejection fraction refractory to therapy is presented. The role of clinical signs, especially “red flags” of amyloidosis,
M. K. Akhverdieva, I. A. Garina, V. V. Zhivaga, M. S. Litvinova, L. A. Khaisheva   +4 more
doaj   +1 more source

Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures [PDF]

, 2016
BACKGROUND: Early diagnosis of familial transthyretin (TTR) amyloid diseases remains challenging because of variable disease penetrance. Currently, patients must have an amyloid positive tissue biopsy to be eligible for disease-modifying therapies ...
Buxbaum, J., Coelho, T., Gelbart, T., Kelly, J., Kurian, S., Novais, M., Salomon, D., Whisenant, T.   +7 more
core   +1 more source

Amyloid Cardiomyopathy: Review of A Fatal Case Report

Архивъ внутренней медицины
Close attention to the problem of amyloid cardiomyopathy in recent years has been caused by a significant increase in the disease detection simultaneously with increased sensitivity and specificity of imaging methods used in cardiological practice, along
O. V. Soldatova, I. Ya. Goryanskaya
doaj   +1 more source

Review of cardiac amyloidosis

Journal of the Practice of Cardiovascular Sciences, 2018
Cardiac amyloidosis is characterized by clinically significant extracellular amyloid infiltration of the heart that is commonly associated with multiorgan involvement depending on the type of amyloid.
Srikant Shivan, Sandeep Seth
doaj   +1 more source

A classic case of amyloid cardiomyopathy [PDF]

BMJ Case Reports, 2012
A 55-year-old-woman with a history of hypertension, dyslipidemia and carpal tunnel syndrome had slowly progressive fatigue, weight loss, early satiety and diarrhoea over a 12-month period. She then developed several syncopal episodes attributed to orthostatic hypotension and one episode of cardiorespiratory arrest secondary to ventricular tachycardia ...
Hayan, Jouni, William G, Morice, S Vincent, Rajkumar, Joerg, Herrmann   +3 more
openaire   +2 more sources

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Mitral and tricuspid stenosis caused by light chain cardiac amyloid deposition

ESC Heart Failure, 2020
Cardiac amyloidosis results in an infiltrative restrictive cardiomyopathy, with a number of characteristic features: biventricular hypertrophy, abnormal myocardial global longitudinal strain with relative apical sparing, biatrial dilation, and small ...
Varinder K. Randhawa, Sneha Vakamudi, Dermot M. Phelan, Christy J. Samaras, Jesse K. McKenney, Mazen Hanna, Antonio L. Perez   +6 more
doaj   +1 more source

Long-term efficacy of tafamidis in patients with transthyretin amyloid cardiomyopathy by National Amyloidosis Centre stage. [PDF]

Eur J Heart Fail
Tafamidis is an approved treatment for patients with transthyretin amyloid cardiomyopathy (ATTR‐CM) based on the 30‐month Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR‐ACT).
Damy T, Wang R, Maurer MS, Gillmore JD, Fontana M.   +4 more
europepmc   +2 more sources

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]

, 2019
Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid, Batchelor, Mark, Bieschke, Jan, Kedia, Niraja, Pittman, Sara K., Sun, Yuanzi, Weihl, Conrad C.   +6 more
core   +1 more source

Diagnostic sensitivity of abdominal fat aspiration in cardiac amyloidosis [PDF]

, 2017
Aims: Congo red staining of an endomyocardial biopsy is the diagnostic gold-standard in suspected cardiac amyloidosis (CA), but the procedure is associated with the risk, albeit small, of serious complications, and delay in diagnosis due to the ...
Botcher, N, Fontana, M, Gilbertson, JA, Gillmore, JD, Gonzalez-Lopez, E, Hawkins, PN, Lachmann, HJ, Mahmood, S, Petrie, A, Quarta, CC, Rezk, T, Rowczenio, D, Sachchithanantham, S, Wechalekar, AD, Whelan, CJ, Youngstein, T   +15 more
core   +1 more source