Results 141 to 150 of about 75,180 (286)

On the social induction of Alzheimer's disease: An index theorem aging model for amyloid formation [PDF]

, 2011
The central 'risk factor' for Alzheimer's disease (AD) is age. From first principles, we construct a mathematical model of protein folding and its in vivo regulation that gives this result in a natural manner.
Deborah Wallace, Rodrick Wallace
core   +1 more source

Amyloid fibrils [PDF]

The FEBS Journal, 2005
openaire   +2 more sources

Bioanalytical TERS and Advanced Data Processing Methods

Journal of Raman Spectroscopy, EarlyView.
Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi, Ankit Dodla, Sarthak Saxena, Twinkle Soni, Sumit Saxena, Shobha Shukla, Bayden R. Wood   +6 more
wiley   +1 more source

Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay

Movement Disorders, EarlyView.
Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya, Nanna Møller Jensen, Dennis W. Dickson, Poul Henning Jensen   +3 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Protein Aggregates and Polyglutamine Tracts In Neurodegenerative Disease [PDF]

, 2018
The incidence of neurodegenerative diseases such as Alzheimer\u27s Disease, Parkinson\u27s Disease, Huntington\u27s Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of ...
Mack, John
core   +1 more source

Eplontersen for Hereditary Transthyretin Amyloidosis With Polyneuropathy: An Exploratory Analysis of Treatment Effect in Male and Female Patients

Muscle &Nerve, EarlyView.
This exploratory analysis of data from the NEURO‐TTRansform trial evaluated sex‐specific responses in patients with ATTRv‐PN who had received eplontersen in NEURO‐TTRansform versus a historical placebo. Eplontersen can lead to substantial decreases in percentage serum TTR levels, arrest neuropathy impairment, and improve patient quality of life ...
Márcia Waddington Cruz, John L. Berk, Yeşim Parman, Morie Gertz, Sami Khella, Markus Weiler, T. Jesse Kwoh, Maksym Pola, Barry Reicher, Jonatan Nåtman, Noel R. Dasgupta, Jonas Wixner   +11 more
wiley   +1 more source

Vibrational Optical Activity of Amyloid Fibrils

ChemPlusChem
AbstractAmyloid fibrils are supramolecular systems showing distinct chirality at different levels of their complex multilayered architectures. Due to the regular long‐range chiral organization, amyloid fibrils exhibit the most intense Vibrational Optical Activity (VOA) signal observed up to now, making VOA techniques: Vibrational Circular Dichroism ...
Zuzanna Majka, Karolina Kwiecień, Agnieszka Kaczor   +2 more
openaire   +3 more sources

Amanita theophili sp. nov. (Amanitaceae) from central Mexico

Nordic Journal of Botany, EarlyView.
Amanita theophili sp. nov., a member of Amanita sect. Amidella (Amanitaceae), is described from temperate pine‐oak forests in Morelos, central Mexico. Morphological features and phylogenetic analyses based on ITS and 28S rDNA sequences confirm its distinct taxonomic status. The new species is morphologically similar to A. peckiana and A.
Evangelina Pérez‐Silva, Edith Garay‐Serrano   +1 more
wiley   +1 more source

Interactions of Amyloid Fibrils with Functional Proteins: Modulating Effect of Polyphenols

East European Journal of Physics
The elucidation of interactions between functional proteins and amyloid fibrils is crucial for understanding the molecular basis of amyloid diseases, which are characterized by protein misfolding and aggregation.
Valeriya Trusova, Uliana Tarabara, Galyna Gorbenko   +2 more
doaj   +1 more source