Results 151 to 160 of about 160,241 (252)

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source

AURAMINE O AS POTENTIAL AMYLOID MARKER: FLUORESCENCE AND MOLECULAR DOCKING STUDIES

East European Journal of Physics, 2017
The applicability of Auramine O to the detection and characterization of lysozyme and serum albumin amyloid fibrils has been assessed using the fluorimetric titration and molecular docking.
K. Vus, U. Tarabara, K. Semenova, V. Viter, O. Nikitina, V. Trusova, G. Gorbenko   +6 more
doaj  

Research Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review

Phytotherapy Research, EarlyView.
Research landscape and mechanistic insights into natural medicines for Alzheimer's disease. ABSTRACT Natural medicines have been widely investigated for Alzheimer's disease (AD), but the development of this field and the relationship between bibliometric themes and experimental evidence remain insufficiently characterized.
Maoning Wang, Xiaolian Zhang, Huaxian Yang, Jianhe Zhao, Wentao Wei, Qian Zhao, Wenjia Wang, Yunhui Hu, Jiansong Fang   +8 more
wiley   +1 more source

Potential of Ginkgo biloba Extract to Intervene in Chronic Inflammation‐Related Diseases

Phytotherapy Research, EarlyView.
Chronic inflammation is a pathological mechanism underpinning many diseases. Ginkgo biloba extract (GBE) is well known for its anti‐inflammatory property. GBE and its active constituents have been shown to attenuate pro‐inflammatory cytokine production, suppress nuclear factor kappa B activation, restore redox homeostasis, and modulate disease‐relevant
Yipeng Lin, Inho Cho, Xue Zhu, Ke Wang, Ling Zhu, Wenchang Wong, Michael Murray, Fanfan Zhou   +7 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Dual‐Component Spidroin‐Based Hydrogels: A Mechanically Tunable Platform for 2D and 3D Cell Culture

Small, EarlyView.
A dual‐component recombinant spider silk hydrogel platform was developed by combining NT2RepCT with a bioactive vitronectin‐functionalized spidroin domain. The hydrogels self‐assemble under physiological conditions, exhibit tunable mechanical properties, and support 2D and 3D cell culture, providing a versatile platform for mechanobiological studies ...
Sanna Korpela, Urmimala Chatterjee, Gabriele Greco, Benjamin Schmuck, Rakesh Kumar, Olga Shilkova, Cecilia Götherström, Anna Rising, Teemu O. Ihalainen   +8 more
wiley   +1 more source

Programmable Chirality Transfer: Seeding‐Directed Co‐Assembly of Functional Molecules With Amyloid Frameworks

Small, EarlyView.
Seeding‐directed co‐assembly enables efficient chirality transfer from chiral amyloid scaffold to achiral functional molecules. Controlled assembly pathways result in hierarchical hybrid supramolecular structures showing enhanced induced electronic circular dichroism (IECD) and/or vibrational circular dichroism (IVCD).
Aleksandra Kołodziejczyk, Joanna Mazurkiewicz, Andrzej J. Kałka, Agnieszka Kaczor   +3 more
wiley   +1 more source

Exploiting Phase Partitioning of a Giant Trimeric Fibrous Protein Scaffold to Potentiate Chitinase‐Driven Antifungal Activity

Small, EarlyView.
Cstalk, a giant fibrous protein, selectively partitions into the dextran‐rich phase in polyethylene glycol/dextran aqueous two‐phase systems, functioning as a recruiter for proteins of interest. This phase‐selective recruitment can be extended to fungal cell walls, enabling the targeted localization of enzymes and enhancing antifungal activity through ...
Ayasa Nagatani, Shogo Yoshimoto, Toki Taira, Rie Wakabayashi, Masahiro Goto, Katsutoshi Hori, Noriho Kamiya   +6 more
wiley   +1 more source

One‐Pot Fabrication of Pentapeptide Bio‐Aerogel via Direct Alcogelation

Small, EarlyView.
A minimal tachykinin‐inspired pentapeptide (TC‐1) self‐assembles in water and ethanol to form robust gels that can be dried in one pot to ultra‐porous aerogels using supercritical carbon dioxide. Solvent choice programs nanoscale packing and bulk mechanics producing lightweight monoliths with high porosity for biomaterials applications, verified by ...
Brody McDonald, Durga Dharmadana, Nevena Todorova, Boyin Liu, Shuaiyu Jiang, Ewan W. Blanch, Céline Valéry   +6 more
wiley   +1 more source

The cytoxocity of amyloid fibrils

, 2011
Amyloid assemblies consist of an organised cross ~-sheet structure and can be formed by many proteins or peptides regardless of peptide sequence. Amyloid has been utilised by many species for a variety of functions, however, inappropriate amyloid ...
Hellewell, Andrew Leslie
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