Results 51 to 60 of about 288,605 (343)
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils
Nature Structural & Molecular Biology, 2020 Amyloid deposits consisting of fibrillar islet amyloid polypeptide (IAPP) in pancreatic islets are associated with beta-cell loss and have been implicated in type 2 diabetes (T2D).
C. Röder +8 more
semanticscholar +1 more source
Biology Open, 2015 Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity.
Laura M. Castellano +4 more
doaj +1 more source
mBio, 2023 Staphylococcus aureus secretes phenol-soluble modulins (PSMs), a family of small, amphipathic, secreted peptides with multiple biologic activities. Community-acquired S.
Xiaogang Wang +5 more
doaj +1 more source
The association of lipids with amyloid fibrils
Journal of Biological Chemistry, 2022 Amyloid formation continues to be a widely studied area because of its association with numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of work on protein aggregation and fibril formation, there are still significant gaps in our understanding of the factors that differentiate toxic amyloid formation in vivo from ...
openaire +2 more sources
Towards Optimal Control of Amyloid Fibrillation
Bulletin of Mathematical Biology, 2023 26pages, 7 ...
Mengshou Wang +3 more
openaire +3 more sources
An Imaging and Systems Modeling Approach to Fibril Breakage Enables Prediction of Amyloid Behavior [PDF]
, 2013 Delineating the nanoscale properties and the dynamic assembly and disassembly behaviors of amyloid fibrils is key for technological applications that use the material properties of amyloid fibrils, as well as for developing treatments of amyloid ...
Xue, Wei-Feng +3 more
core +1 more source
Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
Frontiers in Molecular Neuroscience, 2020 Amyloid plaques are a pathological hallmark of Alzheimer’s disease. The major component of these plaques are highly ordered amyloid fibrils formed by amyloid-β (Aβ) peptides.
Madeleine R. Brown +2 more
doaj +1 more source
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Molecular Neurodegeneration, 2023 Background The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges ...
Arun Upadhyay +6 more
doaj +1 more source
Cryo EM of amyloid fibrils and cellular aggregates
Current Opinion in Structural Biology, 2019 Neurodegenerative and other protein misfolding diseases are associated with the aggregation of a protein, which may be mutated in genetic forms of disease, or the wild type form in late onset sporadic disease.
A. Fitzpatrick, H. Saibil
semanticscholar +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source