Results 71 to 80 of about 160,241 (252)
Advanced Science, EarlyView.Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García +13 more
wiley +1 more source
Nanomechanical Characterization of Apolipoprotein A-I Amyloid Fibrils
East European Journal of Physics, 2020 Amyloid fibrils represent a special type of protein aggregates that are currently receiving enormous attention due to their strong implication in molecular etiology of a wide range of human disorders.
Valeriya Trusova +5 more
doaj +1 more source
Biomolecules, 2022 The division of amyloid fibril particles through fragmentation is implicated in the progression of human neurodegenerative disorders such as Parkinson’s disease.
Sarina Sanami +4 more
doaj +1 more source
Crystallin proteins and amyloid fibrils
Cellular and Molecular Life Sciences, 2008 Improper protein folding (misfolding) can lead to the formation of disordered (amorphous) or ordered (amyloid fibril) aggregates. The major lens protein, alpha-crystallin, is a member of the small heat-shock protein (sHsp) family of intracellular molecular chaperone proteins that prevent protein aggregation.
Ecroyd, Heath, Carver, John
openaire +4 more sources
Pathological and Functional Amyloid Fibrils—Part I
, 2022 Amyloid fibrils have been known to researchers for a long time [...
Turoverov, Konstantin K. +3 more
core +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Food protein-derived amyloids do not accelerate amyloid β aggregation
Scientific Reports, 2023 The deposition of proteins in the form of amyloid fibrils is closely associated with several serious diseases. The events that trigger the conversion from soluble functional proteins into insoluble amyloid are not fully understood. Many proteins that are
M. Mahafuzur Rahman +6 more
doaj +1 more source
Self-Assembly of Amyloid Fibrils That Display Active Enzymes. [PDF]
, 2014 Enzyme immobilization is an important strategy to enhance the stability and recoverability of enzymes and to facilitate the separation of enzymes from reaction products.
Smith, Andrew T +19 more
core +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
UV-light exposed prion protein fails to form amyloid fibrils. [PDF]
PLoS ONE, 2008 Amyloid fibril formation involves three steps; structural perturbation, nucleation and elongation. We have investigated amyloidogenesis using prion protein as a model system and UV-light as a structural perturbant.
Abhay Kumar Thakur, Ch Mohan Rao
doaj +1 more source