Results 91 to 100 of about 8,024 (229)

AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury. [PDF]

, 2015
We evaluated the effect of AAV2- and 17-AAG (17-N-allylamino-17-demethoxygeldanamycin)-mediated upregulation of Hsp70 expression on the survival of retinal ganglion cells (RGCs) injured by optic nerve crush (ONC).
Bekerman, V, Caprioli, J, Gu, L, Hauswirth, WW, Kumar-Singh, R, Kwong, JMK, Nassiri, N, Piri, N, Rhee, KD, Yang, X-J   +9 more
core   +1 more source

Negative [99mTc]Tc ‐DPD Scintigraphy, Presence of Monoclonal Protein and Biopsy Suggestive of AL Amyloidosis in a Patient With Homozygous p.Ala101Val Transthyretin Gene Variant

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amyloidosis is a rare disease associated with the deposition of misfolded proteins that damage multiple organs, leading to a wide range of symptoms. The most frequently implicated proteins in amyloidosis include immunoglobulin Free Light Chains (FLC), related to AL amyloidosis, and transthyretin (TTR), which is responsible for ATTR amyloidosis.
Paulina Kryszpin, Piotr Jachimowski, Łukasz Augustowski, Mateusz Ziarkiewicz, Grzegorz Basak, Marta Lipowska, Marta Legatowicz‐Koprowska, Bogna Ziarkiewicz‐Wróblewska, Monika Gawor‐Prokopczyk   +8 more
wiley   +1 more source

Bildgebende Diagnostik von Nervenkompressionssyndromen [PDF]

, 2018
Zusammenfassung: Kompressionsbedingte Schädigungen peripherer Nerven können die Ursache hartnäckiger Schmerzen im Bereich des Sprunggelenks und Fußes sein. Eine frühzeitige Diagnose ist entscheidend, um den Patienten der richtigen Therapie zuzuführen und
Andreisek, G., Weishaupt, D.
core  

A Review of Tafamidis for the Treatment of Transthyretin-Related Amyloidosis [PDF]

, 2015
Transthyretin (TTR)-related amyloidosis (ATTR) is a devastating disease which affects a combination of organs including the heart and the peripheral nerves, and which has a fatal outcome if not treated within a average of 10 years.
Benson, Merril D., Waddington Cruz, Márcia   +1 more
core   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

Neurodegeneration as a consequence of failed mitochondrial maintenance [PDF]

, 2018
Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears that neuronal homeostasis depends on high-fidelity mitochondria, in particular.
Karbowski, Mariusz, Neutzner, Albert
core  

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Amyloid neuropathy and autonomic dysfunction

Neurology and Clinical Neuroscience, 2022
AbstractThe clinical phenotype of amyloid neuropathy is not uniform. Especially in patients with hereditary amyloid neuropathy, the age at onset and severity of autonomic neuropathy are strongly influenced by the patient’s family history and the mutant gene of transthyretin. In the past 30 years, liver transplantation has been actively performed in the
openaire   +1 more source

Aging of perennial cells and organ parts according to the programmed aging paradigm [PDF]

, 2016
If aging is a physiological phenomenon-as maintained by the programmed aging paradigm-it must be caused by specific genetically determined and regulated mechanisms, which must be confirmed by evidence.
FERRARA, NICOLA, FERRARA, NICOLA, Libertini, Giacinto   +2 more
core   +1 more source