Results 11 to 20 of about 145,378 (214)

Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]

, 2013
Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
core   +6 more sources

Reply to "Sural/Radial Amplitude Ratio in Non-Length-Dependent Neuropathy (NLDN): A Call for More Standardized Methodology and Further Evaluation of Distal NLDN". [PDF]

Muscle Nerve
Muscle &Nerve, Volume 74, Issue 3, Page 761-762, September 2026.
Pegat A, Fargeot G, Bouhour F.
europepmc   +2 more sources

Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]

, 2011
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory, Catherine Parr-Sturgess, Parr-Sturgess, Catherine, Edward Parkin, Mallory Gough, Parkin, Edward   +5 more
core   +5 more sources

Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression

Orphanet Journal of Rare Diseases, 2021
Background Hereditary transthyretin-mediated amyloidosis, also known as ATTRv amyloidosis (v for variant), is a rare, autosomal dominant, fatal disease, in which systemic amyloid progressively impairs multiple organs, leading to disability and death. The
David Adams, Vincent Algalarrondo, Michael Polydefkis, Nitasha Sarswat, Michel S. Slama, Jose Nativi-Nicolau   +5 more
doaj   +1 more source

Neuropathy in Val122Ile Hereditary Transthyretin (ATTR) Amyloidosis: A Multicenter Retrospective Cohort Study. [PDF]

J Peripher Nerv Syst
ABSTRACT Background and Aims The Val122Ile ATTR Amyloidosis has traditionally been linked to cardiac manifestations. Recent studies suggest that neuropathy may be relevant. In this study, we characterized its peripheral nerve manifestations in depth. Methods This was a national, multicenter, observational, retrospective study.
Paranhos AP, Costa MCM, Moreira CL, Dos Santos DF, França MC, de França Nunes RF, do Nascimento OJM, da Silva Batista JA, Cavalcanti EBU, Rodrigues CL, Chaves ÂVF, Kerstenetzky MS, de Brito LA, Marrone CD, Gonçalves MVM, Tomaselli PJ, Marques W.   +16 more
europepmc   +2 more sources

Corneal Confocal Microscopy to Image Small Nerve Fiber Degeneration: Ophthalmology Meets Neurology

Frontiers in Pain Research, 2021
Neuropathic pain has multiple etiologies, but a major feature is small fiber dysfunction or damage. Corneal confocal microscopy (CCM) is a rapid non-invasive ophthalmic imaging technique that can image small nerve fibers in the cornea and has been ...
Ioannis N. Petropoulos, Gulfidan Bitirgen, Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Shazli Azmi, Luca D'Onofrio, Sze Hway Lim, Georgios Ponirakis, Adnan Khan, Hoda Gad, Ibrahim Mohammed, Yacob E. Mohammadi, Ayesha Malik, David Gosal, Christopher Kobylecki, Monty Silverdale, Handrean Soran, Uazman Alam, Rayaz A. Malik, Rayaz A. Malik   +20 more
doaj   +1 more source

Fibril fragmentation in amyloid assembly and cytotoxicity: When size matters [PDF]

, 2010
Amyloid assemblies are associated with several debilitating human disorders. Understanding the intra- and extracellular assembly of normally soluble proteins and peptides into amyloid aggregates and how they disrupt normal cellular functions is therefore
Xue, Wei-Feng, Hellewell, Andrew L., Hewitt, Eric W., Radford, Sheena E.   +3 more
core   +1 more source

hATTR Pathology: Nerve Biopsy Results from Italian Referral Centers

Brain Sciences, 2020
Pathological evidence of amyloid on nerve biopsy has been the gold standard for diagnosis in hereditary transthyretin amyloidosis polyneuropathy (hATTR-PN) for a long time. In this article, we reviewed the pathological findings of a large series of sural
Marco Luigetti, Marina Romozzi, Giulia Bisogni, Davide Cardellini, Tiziana Cavallaro, Andrea Di Paolantonio, Gian Maria Fabrizi, Silvia Fenu, Luca Gentile, Marina Grandis, Gianluca Marucci, Sara Massucco, Anna Mazzeo, Davide Pareyson, Angela Romano, Massimo Russo, Angelo Schenone, Matteo Tagliapietra, Stefano Tozza, Giuseppe Vita, Mario Sabatelli   +20 more
doaj   +1 more source

Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey [PDF]

Iranian Journal of Basic Medical Sciences
Nanomedicine has transformed therapeutic strategies by enabling precise delivery of nucleic acid-based drugs, including small interfering RNA (siRNA), messenger RNA (mRNA), and antisense oligonucleotides.
Dilpreet Singh, Satvir Singh, Nitin Tandon, Akshay Thakur, Neena Bedi   +4 more
doaj   +1 more source

Amyloid neuropathy

Romanian Journal of Neurology, 2009
Amyloidosis is the name given to a group of diseases characterized by the extracellular deposition of insoluble amyloid fibrils in different tissues and organs like kidneys, heart, liver, skin, nerves etc. Clinical manifestations of amyloidosis are determined by the amyloid precursor protein type, by the tissue containing amyloid deposits, and by the ...
Marilena Alexianu, Andrei Dan
openaire   +2 more sources