Results 21 to 30 of about 4,929 (174)

hATTR Pathology: Nerve Biopsy Results from Italian Referral Centers

Brain Sciences, 2020
Pathological evidence of amyloid on nerve biopsy has been the gold standard for diagnosis in hereditary transthyretin amyloidosis polyneuropathy (hATTR-PN) for a long time. In this article, we reviewed the pathological findings of a large series of sural
Marco Luigetti, Marina Romozzi, Giulia Bisogni, Davide Cardellini, Tiziana Cavallaro, Andrea Di Paolantonio, Gian Maria Fabrizi, Silvia Fenu, Luca Gentile, Marina Grandis, Gianluca Marucci, Sara Massucco, Anna Mazzeo, Davide Pareyson, Angela Romano, Massimo Russo, Angelo Schenone, Matteo Tagliapietra, Stefano Tozza, Giuseppe Vita, Mario Sabatelli   +20 more
doaj   +1 more source

Amyloid neuropathy

Romanian Journal of Neurology, 2009
Amyloidosis is the name given to a group of diseases characterized by the extracellular deposition of insoluble amyloid fibrils in different tissues and organs like kidneys, heart, liver, skin, nerves etc. Clinical manifestations of amyloidosis are determined by the amyloid precursor protein type, by the tissue containing amyloid deposits, and by the ...
Marilena Alexianu, Andrei Dan
openaire   +2 more sources

Emerging trends in nanomedicine: The role of RNAi-based therapies and onpattro’s clinical journey [PDF]

Iranian Journal of Basic Medical Sciences
Nanomedicine has transformed therapeutic strategies by enabling precise delivery of nucleic acid-based drugs, including small interfering RNA (siRNA), messenger RNA (mRNA), and antisense oligonucleotides.
Dilpreet Singh, Satvir Singh, Nitin Tandon, Akshay Thakur, Neena Bedi   +4 more
doaj   +1 more source

Lower urinary tract dysfunction in uncommon neurological diseases: A report of the neurourology promotion committee of the International Continence Society

Continence, 2022
The management of patients with neurogenic lower urinary tract dysfunction has been well-described, however this is most frequently discussed for common conditions such as spinal cord injury or multiple sclerosis.
Blayne Welk, Ryuji Sakakibara, Sanjay Sinha, Collette Haslam, Desiree Vrijens, Cristiano Gomes, Stefan De Wachter, Charalampos Konstantinidis, Giulio Del Popolo, Pawan Vasudeva, Marcus J. Drake, Rizwan Hamid   +11 more
doaj   +1 more source

Discovering new peripheral plasma biomarkers to identify cognitive decline in type 2 diabetes

Frontiers in Cell and Developmental Biology, 2022
Type 2 diabetes mellitus (T2DM) is an independent risk factor of Alzheimer’s disease (AD), and thus identifying who among the increasing T2DM populations may develop into AD is important for early intervention.
Haitao Yu, Haitao Yu, Yang Gao, Ting He, Mengzhu Li, Yao Zhang, Jie Zheng, Bijun Jiang, Chongyang Chen, Dan Ke, Yanchao Liu, Yanchao Liu, Jian-Zhi Wang, Jian-Zhi Wang   +13 more
doaj   +1 more source

Therapeutic Potential of αS Evolvability for Neuropathic Gaucher Disease

Biomolecules, 2021
Gaucher disease (GD), the most common lysosomal storage disorder (LSD), is caused by autosomal recessive mutations of the glucocerebrosidase gene, GBA1.
Jianshe Wei, Yoshiki Takamatsu, Ryoko Wada, Masayo Fujita, Gilbert Ho, Eliezer Masliah, Makoto Hashimoto   +6 more
doaj   +1 more source

Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: second edition

Arquivos de Neuro-Psiquiatria, 2023
Hereditary transthyretin amyloidosis with peripheral neuropathy (ATTRv-PN) is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy with over 130 pathogenic variants identified in the TTR gene.
Marcus Vinicius Pinto, Marcondes Cavalcante França, Marcus Vinicius Magno Gonçalves, Marcela Câmara Machado-Costa, Marcos Raimundo Gomes de Freitas, Francisco de Assis Aquino Gondim, Carlo Domenico Marrone, Alberto Rolim Muro Martinez, Carolina Lavigne Moreira, Osvaldo J. M. Nascimento, Anna Paula Paranhos Covaleski, Acary Souza Bulle de Oliveira, Camila Castelo Branco Pupe, Marcia Maria Jardim Rodrigues, Francisco Tellechea Rotta, Rosana Herminia Scola, Wilson Marques, Márcia Waddington-Cruz   +17 more
doaj   +1 more source

Dimethyl Fumarate Ameliorates Lewis Rat Experimental Autoimmune Neuritis and Mediates Axonal Protection. [PDF]

PLoS ONE, 2015
Dimethyl fumarate is an immunomodulatory and neuroprotective drug, approved recently for the treatment of relapsing-remitting multiple sclerosis. In view of the limited therapeutic options for human acute and chronic polyneuritis, we used the animal ...
Kalliopi Pitarokoili, Björn Ambrosius, Daniela Meyer, Lisa Schrewe, Ralf Gold   +4 more
doaj   +1 more source

Nerve Ultrasound Comparison Between Transthyretin Familial Amyloid Polyneuropathy and Chronic Inflammatory Demyelinating Polyneuropathy

Frontiers in Neurology, 2021
Backgrounds: Transthyretin familial amyloid polyneuropathy (TTR-FAP) is frequently misdiagnosed as chronic inflammatory demyelinating polyneuropathy (CIDP) because of similar phenotypes in the two diseases. This study was intended to identify the role of
Kang Du, Ke Xu, Si Cheng, Si Cheng, He Lv, Wei Zhang, Zhaoxia Wang, Yun Yuan, Lingchao Meng   +8 more
doaj   +1 more source

Brazilian consensus for diagnosis, management and treatment of transthyretin familial amyloid polyneuropathy

Arquivos de Neuro-Psiquiatria
Transthyretin familial amyloid polyneuropathy is an autosomal dominant inherited sensorimotor and autonomic polyneuropathy, which if untreated, leads to death in approximately 10 years.
Marcus Vinicius Pinto, Amilton Antunes Barreira, Acary Souza Bulle, Marcos Raimundo Gomes de Freitas, Marcondes Cavalcante França Jr, Francisco de Assis Aquino Gondim, Carlo Domenico Marrone, Wilson Marques Jr, Osvaldo J. M. Nascimento, Francisco Tellechea Rotta, Camila Pupe, Márcia Waddington-Cruz   +11 more
doaj   +1 more source