Results 331 to 340 of about 343,599 (390)

RABGAP1 acts as a sensor to facilitate sorting and processing of amyloid precursor protein

Eden J, Kaufman JG, Cattin-Ortola J, Benedetti L, Nieuwenhuis B, Owen DJ, Lippincott-Schwartz J, Munro S, Gershlick DC.   +8 more
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Amyloid precursor protein and mitochondria

Current Opinion in Neurobiology, 2022
Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
semanticscholar   +3 more sources

Amyloid Precursor Protein

, 2017
A. Raza, V. Bossuyt, T. Godwin
semanticscholar   +2 more sources

Function of amyloid and amyloid protein precursor

Clinical Neurology and Neurosurgery, 1992
A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins

Neurodegenerative Diseases, 2006
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
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Recognition of the Amyloid Precursor Protein by Human gamma-secretase

, 2019
Cleavage of amyloid precursor protein (APP) by the intramembrane protease γ-secretase is linked to Alzheimer's disease (AD). We report an atomic structure of human γ-secretase in complex with a transmembrane (TM) APP fragment at 2.6-angstrom resolution ...
R. Zhou, G. H. Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi   +5 more
semanticscholar   +1 more source

Amyloid precursor protein in Alzheimer's disease

2023
Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya, Gargi, Bhattacharjee, Khushal, Khambhati, Nisarg, Gohil, Priyanka, Singh, Indra, Mani, Dinh-Toi, Chu, Suresh, Ramakrishna, Pau-Loke, Show, Vijai, Singh   +9 more
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Regulation of Amyloid Precursor Protein Cleavage

Journal of Neurochemistry, 1999
Abstract : Multiple lines of evidence suggest that increased production and/or deposition of the β‐amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's disease. A growing list of neuro‐transmitters, growth factors, cytokines, and hormones have been shown to regulate amyloid precursor protein processing.
J, Mills, P B, Reiner
openaire   +2 more sources