Results 341 to 350 of about 343,599 (390)

Processing of Amyloid Precursor Protein and Amyloid Peptide Neurotoxicity

Current Alzheimer Research, 2008
Alzheimer's disease is characterized by the presence of two types of lesions in brain: neurofibrillary tangles and senile plaques. Intraneuronal neurofibrillary tangles are made of paired helical filaments containing hyperphosphorylated microtubule associated protein tau.
Pierrot, Nathalie, Octave, Jean-Noël
openaire   +2 more sources

Physiology and pharmacology of amyloid precursor protein.

Pharmacology and Therapeutics, 2022
Yoonsuk Cho, H. Bae, E. Okun, T. Arumugam, D. Jo   +4 more
semanticscholar   +1 more source

Fermented papaya preparation attenuates β-amyloid precursor protein: β-amyloid–mediated copper neurotoxicity in β-amyloid precursor protein and β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells

Neuroscience, 2006
Recent studies indicate that the deposition of beta-amyloid (Abeta) is related in the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is still not clear. The abnormal interactions of Abeta with metal ions such as copper are implicated in the process of Abeta deposition and oxidative stress in AD brains.
J, Zhang, A, Mori, Q, Chen, B, Zhao
openaire   +2 more sources

β-Amyloid precursor is a PEST protein

Biochemical and Biophysical Research Communications, 1989
The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
R, Siman, G, Christoph
openaire   +2 more sources

Stimulated platelets release amyloid β-protein precursor

Biochemical and Biophysical Research Communications, 1990
Human platelets can be stimulated by thrombin or ionomycin to secrete soluble truncated amyloid beta-protein precursor and particulate membrane fragments which contain C-terminal and N-terminal immunoreactive amyloid beta-protein precursor. This suggests a possible circulating source of beta-protein in serum which may play a role in the formation of ...
G M, Cole, D, Galasko, I P, Shapiro, T, Saitoh   +3 more
openaire   +2 more sources

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Nature, 1991
A. Goate, M. Chartier-Harlin, M. Mullan, Jeremy S. Brown, F. Crawford, L. Fidani, L. Giuffra, A. Haynes, N. Irving, L. James, R. Mant, P. Newton, K. Rooke, P. Roques, C. Talbot, M. Pericak-Vance, A. Roses, R. Williamson, M. Rossor, M. Owen, J. Hardy   +20 more
semanticscholar   +1 more source

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Nature, 1995
D. Games, David John Adams, Ree Alessandrini, R. Barbour, Patricia Borthelette, C. Blackwell, Tony Carr, J. Clemens, T. Donaldson, F. Gillespie, T. Guido, S. Hagopian, K. Johnson-wood, K. Khan, Mike Lee, P. Leibowitz, I. Lieberburg, S. Little, E. Masliah, L. McConlogue, M. Montoya-Zavala, L. Mucke, L. Paganini, E. Penniman, M. Power, D. Schenk, P. Seubert, B. Snyder, F. Soriano, H. Tan, J. Vitale, S. Wadsworth, B. Wolozin, Jun Zhao   +33 more
semanticscholar   +1 more source

Not just amyloid: physiological functions of the amyloid precursor protein family

Nature Reviews Neuroscience, 2017
U. Müller, T. Deller, M. Korte
semanticscholar   +1 more source

AMYLOID PRECURSOR PROTEIN

Alzheimer Disease & Associated Disorders, 1988
G. PERRY, S. LIPPHARDT, P. MULVIHILL, M. KANCHERLA, L. AUTILIO-GAMBETTI, P. GAMBETTI, S. SHARMA, L. MAGGIORA, J. CORNETTE, T. LOBL, B. GREENBERG   +10 more
openaire   +1 more source

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly