Results 71 to 80 of about 337,024 (290)

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]

, 2011
Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L, Holtzman, David M, LaFerla, Frank M, Tran, Hien T   +3 more
core   +2 more sources

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Nature Communications, 2015
The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark of Alzheimer’s disease (AD).
Zhentao Zhang, Ming-ke Song, Xia Liu, Seong Su Kang, D. Duong, N. Seyfried, Xuebing Cao, Liming Cheng, Y. Sun, Shan Ping Yu, J. Jia, A. Levey, K. Ye   +12 more
semanticscholar   +1 more source

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

Pharmaceuticals
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with age. A wealth of evidence indicates that the amyloid β (Aβ) aggregates result from dyshomeostasis between Aβ production and clearance, which plays a pivotal role in the pathogenesis
Xinhua Zhou, Zeyu Zhu, Shaoming Kuang, Kaipeng Huang, Yueping Li, Yuqiang Wang, Haiyun Chen, Maggie Pui Man Hoi, Benhong Xu, Xifei Yang, Zaijun Zhang   +10 more
doaj   +1 more source

TRANSTHYRETIN POLYNEUROPATHY (CLINICAL CASE)

Медицина в Кузбассе, 2023
Amyloidosis is a violation of protein metabolism, accompanied by the formation in tissues of a specific protein-polysaccharide complex (amyloid) of a fibrillar structure, characterized by a high orderliness of fibrils 5-10 nm thick due to the abundance ...
Наталья Викторовна Коробкова, Светлана Алексеевна Зуева, Ольга Валерьевна Рохленко, Вадим Гельевич Мозес, Елена Владимировна Рудаева, Светлана Ивановна Елгина, Кира Борисовна Мозес, Яэль Центер, Наталья Степановна Черных   +8 more
doaj  

A Physiological Role for Amyloid Beta Protein: Enhancement of Learning and Memory [PDF]

, 2008
Amyloid beta protein (A[beta]) is well recognized as having a significant role in the pathogenesis of Alzheimer's disease (AD). The reason for the presence of A[beta] and its physiological role in non-disease states is not clear.
John Morley, Kelvin A. Yamada, Lin Xu, Steven N. Johnson, Susan Farr, William Banks   +5 more
core   +1 more source

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
core   +4 more sources

Model Hirano bodies protect against tau-independent and tau-dependent cell death initiated by the amyloid precursor protein intracellular domain. [PDF]

PLoS ONE, 2012
The main pathological hallmarks of Alzheimer's disease are amyloid-beta plaques and neurofibrillary tangles, which are primarily composed of amyloid precursor protein (APP) and tau, respectively.
Matthew Furgerson, Marcus Fechheimer, Ruth Furukawa   +2 more
doaj   +1 more source

Probing the secrets of Alzheimer's disease using human-induced pluripotent stem cell technology. [PDF]

, 2014
Our understanding of Alzheimer's disease (AD) is still incomplete and, as a result, we lack effective therapies. Reprogramming to generate human-induced pluripotent stem cells provides a new approach to the generation of human neurons that carry the ...
Goldstein, Lawrence SB, Reyna, Sol, Woodruff, Grace   +2 more
core   +1 more source

Oxidation of Cholesterol by Amyloid Precursor Protein and β-Amyloid Peptide [PDF]

Journal of Biological Chemistry, 2005
Alzheimer's disease (AD) is characterized by accumulation of the neurotoxic peptide beta-amyloid, which is produced by proteolysis of amyloid precursor protein (APP). APP is a large membrane-bound copper-binding protein that is essential in maintaining synaptic function and may play a role in synaptogenesis. beta-Amyloid has been shown to contribute to
Daniel L. Alkon, Thomas J. Nelson
openaire   +3 more sources

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol

Cell & Bioscience, 2023
Amyloid β is considered a key player in the development and progression of Alzheimer’s disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest that there may be a link between cholesterol levels and AD pathology ...
Vladimir Rudajev, Jiri Novotny
doaj   +1 more source