Results 81 to 90 of about 82,488 (290)

SYSTEMIC AMYLOIDOSIS: FINDING ON AUTOPSY. REPORT OF TWO CASES (IN SPANISH)

Revista Ciencias Biomédicas, 2014
Introduction: amyloidosis is the extracellular accumulation of amyloid material, which causes damage in the functioning of organs and tissues. It is characterized by the presence of protein folding, which acquire the capacity of self-assembly creating
Martínez-Muñoz Elsa, Baena-Del Valle Javier, Barrios-Barreto Rina, Herrera-Lomonaco Sandra, Redondo-Bermúdez César, Miranda-Marzola María del Carmen   +5 more
doaj  

The PreA4₆₉₅precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons [PDF]

, 1989
H. G. Lemaire, J. Michael Salbaum, Gerd Multhaup, Jie Kang, Richard M. Bayney, Axel Unterbeck, Konrad Beyreuther, Benno Müller‐Hill   +7 more
openalex   +1 more source

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems, EarlyView.
This review outlines recent advances in integrating artificial intelligence with microphysiological systems for nanoparticle evaluation. It highlights data‐driven optimization, image‐based prediction, and AI‐enabled analysis frameworks that advance translational research and support the development of personalized nanomedicine. Nanoparticles (NPs) play
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
wiley   +1 more source

Human cerebrospinal fluid 6E10-immunoreactive protein species contain amyloid precursor protein fragments.

PLoS ONE, 2019
In a previous study, we reported that levels of two types of protein species-a type of ~55-kDa species and a type of ~15-kDa species-are elevated in the lumbar cerebrospinal fluid (CSF) of cognitively intact elderly individuals who are at risk for ...
Marianne K O Grant, Maureen Handoko, Malgorzata Rozga, Gunnar Brinkmalm, Erik Portelius, Kaj Blennow, Karen H Ashe, Kathleen R Zahs, Peng Liu   +8 more
doaj   +1 more source

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. [PDF]

, 1989
Dmitry Goldgaber, H. Harris, Timothy Hla, T Maciag, Robert Donnelly, J. Steven Jacobsen, Michael P. Vitek, D. C. Gajdusek   +7 more
openalex   +1 more source

Redundancy and divergence in the amyloid precursor protein family

FEBS Letters, 2013
Gene duplication provides genetic material required for functional diversification. An interesting example is the amyloid precursor protein (APP) protein family. The APP gene family has experienced both expansion and contraction during evolution. The three mammalian members have been studied quite extensively in combined knock out models.
S. Ali M. Shariati, Bart De Strooper
openaire   +3 more sources

Neuroaxonal Dystrophy With Osteopetrosis Associated With a Novel Biallelic Nonsense Homozygous Variant in BORCS5

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Neuroaxonal dystrophy (NAD) with osteopetrosis syndrome (OMIM # 600329) was first reported in a consanguineous Moroccan Jewish family. However, to date, no genetic variant has been linked to this disease. We report on sibs, born to consanguineous Pakistani parents identified prenatally with cerebral ventriculomegaly and agenesis of the corpus ...
Yael Fisher, Orli Greenberg, Patrick Shannon, Andrea Staines, Bobbi McGivern, Melanie Patricia Napier, David Chitayat   +6 more
wiley   +1 more source

Amyloid pathology in the brain after ischemia

Folia Neuropathologica, 2019
As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities ...
Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław Czuczwar   +3 more
doaj   +1 more source

The expression of the amyloid precursor protein (APP) is regulated by two GC-elements in the promoter [PDF]

, 1992
Peter Pollwein, Colin L. Masters, K Beyreuther   +2 more
openalex   +1 more source

Genetics of Response to ECT, TMS, Ketamine and Esketamine

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Treatment‐resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined.
Clio E. Franklin, Murat Altinay, Kala Bailey, Mahendra T. Bhati, Brent R. Carr, Susan K. Conroy, Khurshid Khurshid, William M. McDonald, Brian J. Mickey, James W. Murrough, Sean M. Nestor, Thomas Nickl‐Jockschat, Irving M. Reti, Gerard Sanacora, Nicholas T. Trapp, Biju Viswanath, Jesse H. Wright, Peter P. Zandi, James B. Potash   +18 more
wiley   +1 more source