Results 121 to 130 of about 36,206 (272)

Herpes simplex virus interferes with amyloid precursor protein processing [PDF]

, 2005
Background The early events underlying Alzheimer's disease (AD) remain uncertain, although environmental factors may be involved. Work in this laboratory has shown that the combination of herpes simplex virus type 1 (HSV1) in brain and carriage of the
Dobson, C.B., Itzhaki, R.F., Parkin, E.T., Shipley, S.J.   +3 more
core   +4 more sources

Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Advanced Science
Alzheimer's disease (AD), the most prevalent type of dementia, is characterized by a biological process that begins with the development of AD neuropathologic change (ADNPC) while individuals remain asymptomatic.
Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng   +19 more
doaj   +1 more source

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer's Disease. [PDF]

, 2016
Alzheimer\u2019s disease (AD), since its characterization as a precise form of dementia with its own pathological hallmarks, has captured scientists\u2019 attention because of its complexity.
AGOSTINI, MARIO, FASOLATO, CRISTINA
core   +1 more source

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta [PDF]

, 2017
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer’s disease are associated with mutations in APP that increase toxic ...
A Bour, B Kozera, C Haass, C Haass, CJ Taylor, D Kogel, D Schubert, DM Mann, E Kojro, E Thornton, EM Mutisya, F Corrigan, F Corrigan, FS Esch, HK Anandatheerthavarada, I Trounce, IA Trounce, J Clarke, JE Pierce, JK Parks, JO Holloszy, JR Ciallella, JT Jarrett, KJ Livak, L Devi, M Citron, M Gralle, M Manczak, M Mullan, MI Sanchez, MI Sanchez, MP Murphy, MS Forman, N Krako, N Milosch, ND Belyaev, NJ Bergen Van, O Rackham, PD Ray, PH Reddy, PJ Crouch, PM Schaefer, R Vassar, RS Williams, S Ayton, S Hauptmann, S Plummer, SC Lim, SJ Kish, SJ Kish, SM Cardoso, T Harkany, T Itoh, TT Yang, U Keil, V Rhein, V Rhein, V Shukla, VA Morais, WD Parker Jr., X Wang, Y Goodman   +61 more
core   +3 more sources

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

eLife, 2016
γ-secretase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone amyloid-beta (Aβ) peptides, which are centrally implicated in the pathogenesis of Alzheimer’s disease (AD).
David M Bolduc, Daniel R Montagna, Matthew C Seghers, Michael S Wolfe, Dennis J Selkoe   +4 more
doaj   +1 more source

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein [PDF]

, 2008
Vivian Hook, Mark S. Kindy, Gregory Hook
openalex   +1 more source

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome

Neurobiology of Disease, 2015
Neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in Down syndrome (DS). Previous evidence provided a causal relationship between neurogenesis impairment and malfunctioning of the mitogenic ...
Andrea Giacomini, Fiorenza Stagni, Stefania Trazzi, Sandra Guidi, Marco Emili, Elizabeth Brigham, Elisabetta Ciani, Renata Bartesaghi   +7 more
doaj   +1 more source

Genetic Targeting Aromatase in Male Amyloid Precursor Protein Transgenic Mice Down-Regulates β-Secretase (BACE1) and Prevents Alzheimer-Like Pathology and Cognitive Impairment [PDF]

, 2010
Carrie McAllister, Jiangang Long, Adrienne Bowers, Aaron Walker, Philip Cao, Shin-Ichiro Honda, Nobuhiro Harada, Matthias Staufenbiel, Yong Shen, Rena Li   +9 more
openalex   +1 more source

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

PLoS ONE, 2014
Altered production of β-amyloid (Aβ) from the amyloid precursor protein (APP) is closely associated with Alzheimer's disease (AD). APP has a number of homo- and hetero-dimerizing domains, and studies have suggested that dimerization of β-secretase derived APP carboxyl terminal fragment (CTFβ, C99) impairs processive cleavage by γ-secretase increasing ...
Jung J.I., Premraj S., Cruz P.E., Ladd T.B., Kwak Y., Koo E.H., Felsenstein K.M., Golde T.E., Ran Y.   +8 more
openaire   +4 more sources

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

Nature Communications, 2017
Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in ...
Zhentao Zhang, Obiamaka Obianyo, Elfriede Dall, Yuhong Du, Haian Fu, Xia Liu, Seong Su Kang, Mingke Song, Shan-Ping Yu, Chiara Cabrele, Mario Schubert, Xiaoguang Li, Jian-Zhi Wang, Hans Brandstetter, Keqiang Ye   +14 more
doaj   +1 more source