Localization and regional distribution of p23/TMP21 in the brain
Neurobiology of Disease, 2008 Sequential processing of amyloid precursor protein by β- and γ-secretases generates Alzheimer's disease (AD)-associated β-amyloid peptides. Recently it was reported that the transmembrane protein p23/TMP21 associates with γ-secretase, and negatively ...
Kulandaivelu S. Vetrivel +6 more
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Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter +6 more
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Loss of Function of ATXN1 Increases Amyloid β-Protein Levels by Potentiating β-Secretase Processing of β-Amyloid Precursor Protein [PDF]
, 2010 Can Zhang +5 more
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Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation [PDF]
, 2023 István Hajdú +3 more
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Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin metalloprotease ADAM10 [PDF]
, 2001 Elvira Lopez‐Perez +5 more
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Neurobiology of Disease, 2002 A novel presenilin 1 mutation, insR352, associated with a frontal temporal dementia phenotype has been identified (E. A. Rogaeva et al., 2001, Neurology 57, 621–625).
Zareen Amtul +14 more
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Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid β Protein Production via the β-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling [PDF]
, 2005 Il‐Sang Yoon +3 more
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Apolipoprotein Receptor 2 and X11α/β Mediate Apolipoprotein E-Induced Endocytosis of Amyloid-β Precursor Protein and β-Secretase, Leading to Amyloid-β Production [PDF]
, 2007 Xiangyuan He +4 more
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The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase
Frontiers in Bioscience-LandmarkBackground: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP).
Yuan Li +4 more
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Activity of α‐Secretase as the Common Final Effector of Protein Kinase C‐Dependent and ‐Independent Modulation of Amyloid Precursor Protein Metabolism [PDF]
, 1999 Marco Racchi +3 more
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