Results 141 to 150 of about 36,206 (272)

The Role of Presenilin-1 in the γ-Secretase Cleavage of the Amyloid Precursor Protein of Alzheimer's Disease [PDF]

, 2000
Jean‐Noël Octave, Rachid Essalmani, Bernadette Tasiaux, Jean Ménager, Christian Czech, Luc Mercken   +5 more
openalex   +1 more source

Secretase promotes AD progression: simultaneously cleave Notch and APP

Frontiers in Aging Neuroscience
Alzheimer’s disease (AD) involves complex pathological mechanisms. Secretases include membrane protein extracellular structural domain proteases and intramembrane proteases that cleave the topology to type I or type II.
Ke-Fan Yang, Jing-Yi Zhang, Mei Feng, Kuo Yao, Yue-Yang Liu, Ming-Sheng Zhou, Hui Jia, Hui Jia   +7 more
doaj   +1 more source

β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase [PDF]

, 2005
Hon Kit Wong, Takashi Sakurai, Fumitaka Oyama, Kumi Kaneko, Koji Wada, Haruko Miyazaki, Masaru Kurosawa, Bart De Strooper, Paul Säftig, Nobuyuki Nukina   +9 more
openalex   +1 more source

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch [PDF]

, 2001
Magdalena Sastre, Harald Steiner, Klaus Fuchs, Anja Capell, Gerd Multhaup, Margaret M. Condron, David B. Teplow, Christian Haass   +7 more
openalex   +1 more source

Equimolar Production of Amyloid β-Protein and Amyloid Precursor Protein Intracellular Domain from β-Carboxyl-terminal Fragment by γ-Secretase [PDF]

, 2006
Nobuto Kakuda, Satoru Funamoto, Sousuke Yagishita, Mako Takami, Satoko Osawa, Naoshi Dohmae, Yasuo Ihara   +6 more
openalex   +1 more source

CHIPstabilizes amyloid precursor protein via proteasomal degradation and p53‐mediated trans‐repression of β‐secretase [PDF]

, 2015
Amir Kumar Singh, Uttam Pati
openalex   +1 more source

Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production [PDF]

, 2009
Sarah E. Hoey, Robert J. Williams, Michael S. Perkinton   +2 more
openalex   +1 more source

Internalization of Exogenously Added Memapsin 2 (β-Secretase) Ectodomain by Cells Is Mediated by Amyloid Precursor Protein [PDF]

, 2004
Xiangping Huang, Wan‐Pin Chang, Gerald Koelsch, Robert T. Turner, Florea Lupu, Jordan Tang   +5 more
openalex   +1 more source

Proteolysis at the secretase and amyloidogenic cleavage sites of theβ-amyloid precursor protein by acetylcholinesterase and butyrylcholinesterase using model peptide substrates

, 1993
Mark de Serres, Douglas B. Sherman, William G. Chestnut, B M Merrill, O. Humberto Viveros, Emanuel J. Diliberto   +5 more
openalex   +2 more sources

Presenilin 1 Stabilizes the C-terminal Fragment of the Amyloid Precursor Protein Independently of γ-Secretase Activity [PDF]

, 2004
Didier Pitsi, Jean‐Noël Octave
openalex   +1 more source