Results 161 to 170 of about 36,206 (272)

Bridging the gaps in alzheimer's disease: a comprehensive review of current and emerging therapies. [PDF]

Inflammopharmacology
Mostafa RE, Asaad GF.
europepmc   +1 more source

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein [PDF]

, 2011
Sarah A. Sagi, Christian Lessard, Kellen D. Winden, Hiroko Maruyama, Jeremy C. Koo, Sascha Weggen, Thomas Kukar, Todd E. Golde, Edward H. Koo   +8 more
openalex   +1 more source

Experimental and translational models of Alzheimer's disease: From neurodegeneration to novel therapeutic insights. [PDF]

J Prev Alzheimers Dis
Khan N, De S, Boddu S, Pravala N.
europepmc   +1 more source

Low Density Lipoprotein Receptor-related Protein (LRP) Interacts with Presenilin 1 and Is a Competitive Substrate of the Amyloid Precursor Protein (APP) for γ-Secretase [PDF]

, 2005
Alberto Lleó, Elaine Waldron, Christine A. F. Von Arnim, Lauren Herl, Michele M. Tangredi, Ithan D. Peltan, Dudley K. Strickland, Edward H. Koo, Bradley T. Hyman, Claus U. Pietrzik, Oksana Berezovska   +10 more
openalex   +1 more source

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]

, 2019
Bateman, Randall J.
core   +1 more source

FAD Mutations in Presenilin-1 or Amyloid Precursor Protein Decrease the Efficacy of a γ-Secretase Inhibitor: Evidence for Direct Involvement of PS1 in the γ-Secretase Cleavage Complex

, 2000
Weiming Xia, Beth L. Ostaszewski, W. Taylor Kimberly, Talat Rahmati, Chad L. Moore, Michael S. Wolfe, Dennis J. Selkoe   +6 more
openalex   +2 more sources

APP-C31 pathology as a target in neurodegenerative diseases. [PDF]

J Biomed Sci
Yip KC, Ho WF, Liu Y, Dawe GS.
europepmc   +1 more source

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

, 2015
Christian Lessard, Barbara A. Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E. Golde, Edward H. Koo   +5 more
openalex   +2 more sources

Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network [PDF]

, 2000
Daniel Skovronsky, D.Blaine Moore, Marcos E. Milla, Robert W. Doms, Virginia M.‐Y. Lee   +4 more
openalex   +1 more source

Membrane-anchored metalloprotease MDC9 has an α-secretase activity responsible for processing the amyloid precursor protein

, 1999
Hisashi Koike, Shigeo Tomioka, Hiroyuki Sorimachi, Takaomi C. Saido, Kei Maruyama, Akira Okuyama, Atsuko Fujisawa‐Sehara, Shigeo Ohno, Koichi Suzuki, Shoichi Ishiura   +9 more
openalex   +2 more sources