Bacterial fermentation and isotope labelling optimized for amyloidogenic proteins [PDF]
Microbial Biotechnology, 2021 Summary We developed a cost sensitive isotope labelling procedure using a fed‐batch fermentation method and tested its efficiency producing the 15N‐, 13C‐ and 15N/13C‐labelled variants of an amyloidogenic miniprotein (E5: EEEAVRLYIQWLKEGGPSSGRPPPS).
István Vida +7 more
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Misfolding of Amyloidogenic Proteins and Their Interactions with Membranes [PDF]
Biomolecules, 2013 In this paper, we discuss amyloidogenic proteins, their misfolding, resulting structures, and interactions with membranes, which lead to membrane damage and subsequent cell death.
Annalisa Relini +2 more
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Controversial Properties of Amyloidogenic Proteins and Peptides: New Data in the COVID Era [PDF]
Biomedicines, 2023 For a long time, studies of amyloidogenic proteins and peptides (amyloidogenic PPs) have been focused basically on their harmful properties and association with diseases.
Andrei Surguchov +3 more
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The Diagnostic Potential of Amyloidogenic Proteins. [PDF]
Int J Mol Sci, 2021 Neurodegenerative disorders are a highly prevalent class of diseases, whose pathological mechanisms start before the appearance of any clear symptoms. This fact has prompted scientists to search for biomarkers that could aid early treatment. These currently incurable pathologies share the presence of aberrant aggregates called amyloids in the nervous ...
Jin Y +6 more
europepmc +6 more sources
Bioinformatic identification of previously unrecognized amyloidogenic proteins. [PDF]
J Biol Chem, 2022 Low-complexity domains (LCDs) of proteins have been shown to self-associate, and pathogenic mutations within these domains often drive the proteins into amyloid aggregation associated with disease. These domains may be especially susceptible to amyloidogenic mutations because they are commonly intrinsically disordered and function in self-association ...
Rosenberg GM +5 more
europepmc +5 more sources
Amyloidogenic proteins in the SARS-CoV and SARS-CoV-2 proteomes [PDF]
Nature Communications, 2023 Bhardwaj et al., have explored the proteomes of SARS-CoV and SARS-CoV-2, and have demonstrated the amyloid formation of viral proteins, in vitro, through diverse biophysical techniques.
Taniya Bhardwaj +14 more
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Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson’s Disease [PDF]
Journal of Parkinson’s Disease, 2020 It was recently shown (Sampson et al., Elife 9 , 2020) that an amyloidogenic protein, CsgA, present in E. coli biofilms in the gut can trigger Parkinson’s disease in mice.
Tony Werner +2 more
doaj +2 more sources
Insights into Missense SNPs on Amyloidogenic Proteins [PDF]
ProteomesBackground: Amyloidogenic proteins, a heterogenous group of proteins characterized by their ability to form amyloid fibrils, lead to pathological conditions when they undergo abnormal folding and self-assembly.
Fotios P. Galanis +4 more
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Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. [PDF]
J Magn Reson, 2017 The advancement in site-directed spin labeling of proteins has enabled EPR studies to expand into newer research areas within the umbrella of protein-membrane interactions. Recently, membrane remodeling by amyloidogenic and non-amyloidogenic proteins has gained a substantial interest in relation to driving and controlling vital cellular processes such ...
Varkey J, Langen R.
europepmc +4 more sources
Evolvability of Amyloidogenic Proteins in Human Brain. [PDF]
J Alzheimers Dis, 2018 Currently, the physiological roles of amyloidogenic proteins (APs) in human brain, such as amyloid-β and α-synuclein, are elusive. Given that many APs arose by gene duplication and have been resistant against the pressures of natural selection, APs may be associated with some functions that are advantageous for survival of offspring.
Hashimoto M +7 more
europepmc +4 more sources