Results 121 to 130 of about 69,622 (226)

Elucidating the Role of Lipids in the Aggregation of Amyloidogenic Proteins. [PDF]

Acc Chem Res, 2023
Kurouski D.
europepmc   +1 more source

The spleen–brain axis in Alzheimer's disease and related dementias: Integrating immune and metabolic regulation

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Emerging evidence highlights the central role of peripheral immune–metabolic regulation in the pathogenesis of Alzheimer's disease and related dementias (ADRD). Among peripheral organs, the spleen has gained increasing attention as a critical immune–metabolic hub linking systemic homeostasis to central neurodegeneration.
Jingsi Yan, Jiayu Zhang, Xinyi Ye, Huihong Wang, Hang Li, Weirong Li, Huifei Wu, Wei Zhao   +7 more
wiley   +1 more source

Nanoscale Analysis beyond Imaging by Atomic Force Microscopy: Molecular Perspectives on Oncology and Neurodegeneration

Small Science
Nanobiomedicine promises to revolutionize life quality and expectancy of patients with cognitive impairment and cancer malignancies, via unraveling key molecular processes related to their onset useful as biomarkers of disease to develop and improve the ...
Carlos Marcuello, KeeSiang Lim, Giacomo Nisini, Vadim S. Pokrovsky, João Conde, Francesco Simone Ruggeri   +5 more
doaj   +1 more source

Unveiling the Effects of Copper Ions in the Aggregation of Amyloidogenic Proteins. [PDF]

Molecules, 2023
Oliveri V.
europepmc   +1 more source

Functional characterization of TasA and TapA in the formation of the amyloid fiber in Bacillus subtilis [PDF]

, 2017
Introduction Functional amyloids are a very heterogeneous family of amyloid proteins widespread in nature, from humans to bacteria. Unlike their “pathogenic” relatives, implicated in several neurodegenerative diseases, functional amyloids play important
Conejero-Lara, Francisco, Cámara-Almirón, Jesús, Morel, Bertrand, Romero, Diego   +3 more
core  

The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factors converge on neuromodulatory subcortical systems to confer AD risk or resilience.
Alfie Wearn, Kate M. Onuska, Taylor W. Schmitz, Gary R. Turner, R. Nathan Spreng   +4 more
wiley   +1 more source

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

eLife, 2016
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation.
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly   +17 more
doaj   +1 more source

Development of fluorophores for the detection of oligomeric aggregates of amyloidogenic proteins found in neurodegenerative diseases. [PDF]

Front Chem, 2023
Teppang KL, Zhao Q, Yang J.
europepmc   +1 more source

Characterizing Alzheimer’s Disease and Related Dementia in a Hypertension Population Within the State of Florida Using Electronic Health Record–Based Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 751-762, March 2026.
Hypertension is a known modifiable risk factor for Alzheimer’s disease and related dementia (ADRD). However, it is unknown how variance in hypertension control, antihypertensive medications, and social determinants of health, such as social deprivation index (SDI), influence the risk of developing ADRD.
Eissa A. Jafari, Mona Alshahawey, Muhammad A. Zaman, Steven M. Smith, Yan Gong, Glenn E. Smith, Caitrin W. McDonough   +6 more
wiley   +1 more source

Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases. [PDF]

Front Physiol, 2023
Reed AL, Mitchell W, Alexandrescu AT, Alder NN.   +3 more
europepmc   +1 more source