Results 131 to 140 of about 69,622 (226)

Astragalus Polysaccharides Can Effectively Alleviate Cognitive Impairment in Mice With Alzheimer's Disease by Regulating the Gut Microbiota

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
This schematic diagram illustrates that Astragalus polysaccharides improve cognitive dysfunction in 3xTg AD mice by regulating the gut‐brain axis. APS ameliorates gut microbiota and enhances intestinal barrier function, thereby reducing systemic and central inflammation, inhibiting microglial overactivation, and alleviating Aβ deposition and Tau ...
Xilian Wang, Xinyun Ge, Xin Di, Zhiyan Zou, Dan Lei, Zihao Wang, Jiaqiang Hou, Yan Yang, Wanxue Zhang, Yuan Yin, Xinnuo Lei, Yu Long, Xuemin Jian, Xiaoan Li   +13 more
wiley   +1 more source

Therapeutic Efficacy and Safety Profile of Eplontersen in Hereditary Transthyretin‐Mediated Amyloidosis: A Systematic Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Hereditary transthyretin‐mediated amyloidosis (hATTR) is a disorder that affects several body systems and can result in life‐threatening conditions like cardiomyopathy and polyneuropathy. For treatment of hATTR in the new medical realm, there is a breakthrough discovery of a medicine called Eplontersen, which targets the underlying ...
Zeel Vishnubhai Patel, Verkha Kumari, Paras, Bethineedi Lakshmi Deepak, Priyadarshi Prajjwal, Kolanu Nikhil Deep, Rakhi Bai, Serene Sara John, Omniat Amir Hussin   +8 more
wiley   +1 more source

Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins.

PLoS ONE, 2014
An amyloidogenic region (AR) in a protein sequence plays a significant role in protein aggregation and amyloid formation. We have investigated the sequence complexity of AR that is present in intrinsically disordered human proteins.
Swagata Das, Uttam Pal, Supriya Das, Khyati Bagga, Anupam Roy, Arpita Mrigwani, Nakul C Maiti   +6 more
doaj   +1 more source

Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins

Biochimica et Biophysica Acta (BBA) - General Subjects, 2017
Alkaptonuria (AKU) is an ultra-rare inborn error of metabolism characterized by homogentisic acid (HGA) accumulation due to a deficient activity of the homogentisate 1.2-dioxygenase (HGD) enzyme. This leads to the production of dark pigments that are deposited onto connective tissues, a condition named 'ochronosis' and whose mechanisms are not ...
BRACONI, DANIELA, MILLUCCI, LIA, BERNINI, ANDREA, SPIGA, OTTAVIA, LUPETTI, PIETRO, MARZOCCHI, BARBARA, NICCOLAI, NERI, BERNARDINI, GIULIA, SANTUCCI, ANNALISA   +8 more
openaire   +3 more sources

Preclinical advances in antibodies against N‐terminal Aβ4‐x species for Alzheimer's disease and cerebral amyloid angiopathy

Ibrain, Volume 12, Issue 1, Page 52-64, Spring 2026.
This review provides an update on monoclonal and polyclonal antibodies developed to specifically target amyloid beta (Aβ) truncated species starting at residue phenylalanine 4 (Aβ4‐x) in Alzheimer's disease and cerebral amyloid angiopathy preclinical studies (in vitro and in vivo models).
Maria Luisa Valle, Donatello Arienzo
wiley   +1 more source

“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders

Frontiers in Neuroscience
Intra- or extracellular aggregates of proteins are central pathogenic features in most neurodegenerative disorders. The accumulation of such proteins in diseased brains is believed to be the end-stage of a stepwise aggregation of misfolded monomers to ...
Silvia Zampar, Silvia Zampar, Sonja E. Di Gregorio, Sonja E. Di Gregorio, Gustavo Grimmer, Gustavo Grimmer, Joel C. Watts, Joel C. Watts, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson, Martin Ingelsson   +12 more
doaj   +1 more source

Plasmonics‐Enhanced Characterization of Cervid PrP (87–114) Fragment Aggregates in Solution

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Multimodal nanophotonics platform combining plasmon‐enhanced imaging, label‐free SERS, and optical staining reveals new insights into the aggregation of the cervid PrP (87–114) fragment, an amyloidogenic sequence linked to chronic wasting disease susceptibility.ABSTRACTWe performed a multimodal characterisation of self‐assembled fibrillar aggregates ...
Shinki Midha, Aishwarya Sriraman, Lyudmyla Dorosh, Holger Wille, Maria Stepanova   +4 more
wiley   +1 more source

New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles

Small, Volume 22, Issue 15, 12 March 2026.
Gold and upconverting nanoparticles coated with alpha‐synuclein were exploited to produce a quasi‐monolayer hybrid film. The film was then characterized, and its behaviour as a primary optical nano‐thermometer was studied. The film was also used in a proof‐of‐concept study of image‐based optical nanothermometry exploiting a home‐built up‐conversion ...
Emil Milan, Roberto Tira, Chiara Cressoni, Federico Antonio Giacomazzi, Patrizia Canton, Michael Assfalg, Adolfo Speghini   +6 more
wiley   +1 more source

Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases. [PDF]

J Biol Chem, 2022
Murakami K, Izuo N, Bitan G.
europepmc   +1 more source

Graphene Triggers Inflammation in Murine Microglia via Phagocytosis

Small Science, Volume 6, Issue 3, March 2026.
Phagocytosis of single‐layer graphene by microglia triggers inflammatory activation without cytotoxicity. Small carbon nanotubes elicit similar responses, whereas larger graphene nanoplatelets do not. Proteomic analysis reveals effects on inflammation, cytoskeleton, and proliferation, highlighting the importance of graphene stability for safe neural ...
Pratika Rai, Robert Subirana Slotos, Ahmar Hasnain, Emma Walter, Marina Mantellatto Grigoli, Irini Petrou, Mario Dejung, Jia‐Xuan Chen, Oliver Tüscher, Alexey Tarasov, Kristina Endres   +10 more
wiley   +1 more source