Development of molecular tools for diagnosis of Alzheimer's disease that are based on detection of amyloidogenic proteins. [PDF]
Prion, 2021 Kulichikhin KY +8 more
europepmc +1 more source
Synapse, Volume 80, Issue 2, March 2026.ABSTRACT The accumulation of tau tangles and Aβ plaques are prominent neuropathologies that characterize Alzheimer's disease (AD) and Down syndrome (DS). Continuous developments of PET tracers as biomarkers can be supported by autoradiography to validate effectiveness and accuracy of binding properties that elucidate the pathophysiology of DSAD and AD.
Agnes P. Biju +6 more
wiley +1 more source
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death [PDF]
, 2016 Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase
Fernández, Ana M. +5 more
core
Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron +3 more
wiley +1 more source
Identification of amyloidogenic proteins in the microbiomes of a rat Parkinson's disease model and wild-type rats. [PDF]
Protein Sci, 2021 Christensen LFB +6 more
europepmc +1 more source
Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions
Traffic, Volume 27, Issue 1, March 2026.Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang +7 more
wiley +1 more source
Deuterium trafficking, mitochondrial dysfunction, copper homeostasis, and neurodegenerative disease
Frontiers in Molecular BiosciencesDeuterium is a natural heavy isotope of hydrogen, containing an extra neutron. Eukaryotic organisms have devised complex metabolic policies that restrict the amount of deuterium reaching the mitochondria, because it damages the ATPase pumps, leading to ...
Stephanie Seneff +2 more
doaj +1 more source
SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration. [PDF]
Biochem Biophys Res Commun, 2021 Idrees D, Kumar V.
europepmc +1 more source
In silico studies on potential binding sites of amyloid inhibitor compounds on amyloid beta peptide [PDF]
, 2012 The formation of structurally similar insoluble fibrillar protein aggregates, called amyloids, is known to cause several neuronal and non-neuronal degenerative diseases such as Alzheimer‟s disease, Parkinson‟s disease, Huntington‟s disease and Diabetes ...
Rudra, Sumon
core
The Journal of Physiology, Volume 604, Issue 6, Page 2400-2410, 15 March 2026.Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland +4 more
wiley +1 more source