Results 151 to 160 of about 69,622 (226)

Controlling interfacial protein adsorption, desorption and aggregation in biomolecular condensates

Nature Communications
Aggregation of amyloidogenic proteins is linked to age-related diseases. The presence of interfaces can affect their aggregation mechanism, often speeding up aggregation.
Brent S. Visser, Merlijn H. I. van Haren, Wojciech P. Lipiński, Kirsten A. van Leijenhorst-Groener, Mireille M.A.E. Claessens, Marcos V. A. Queirós, Carlos H. I. Ramos, Jorine Eeftens, Evan Spruijt   +8 more
doaj   +1 more source

Natural and Synthetic Derivatives of Hydroxycinnamic Acid Modulating the Pathological Transformation of Amyloidogenic Proteins. [PDF]

Molecules, 2020
Muronetz VI, Barinova K, Kudryavtseva S, Medvedeva M, Melnikova A, Sevostyanova I, Semenyuk P, Stroylova Y, Sova M.   +8 more
europepmc   +1 more source

An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ

npj Parkinson's Disease
Amyloid aggregation is associated with neurodegenerative disease and its modulation is a focus of drug development. We developed a chemical proteomics pipeline to probe the mechanism of action of anti-amyloidogenic compounds.
P. Stalder, T. Serdiuk, D. Ghosh, Y. Fleischmann, N. Ait-Bouziad, J.-P. Quast, L. Malinovska, A. Ouared, A. Davranche, W. Haenseler, C. Boudou, E. Tsika, J. Stöhr, R. Melki, R. Riek, N. de Souza, P. Picotti   +16 more
doaj   +1 more source

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme. [PDF]

J Mol Biol, 2020
Ye Y, Klenerman D, Finley D.
europepmc   +1 more source

Egg yolk platelet proteins from Xenopus laevis are amyloidogenic.

Folia histochemica et cytobiologica, 2002
The association of amphibian (Xenopus laevis) egg yolk platelet proteins, represented predominantly by lipovitellin, was studied as a model of the formation of amyloid deposits. Two kinds of molecular organization formed by this protein material - native and heat-denatured - were found to exhibit amyloid properties although they differ significantly in
Zemanek, Grzegorz, Konieczny, L., Piekarska, Barbara, Rybarska, J., Stopa, Barbara, Spólnik, Paweł, Urbanowicz, B., Nowak, Mateusz, Król, M., Roterman-Konieczna, Irena   +9 more
openaire   +2 more sources

Dysfunction of the Autophagy System and MDM2-p53 Axis Leads to the Accumulation of Amyloidogenic Proteins in Angelman Syndrome Models. [PDF]

Int J Mol Sci
Martins de Almeida JF, Contestabile M, Tonazzini I, De Cesari C, Baroncelli L, Martini C, Daniele S.   +6 more
europepmc   +1 more source

On Levodopa Interactions with Brain Disease Amyloidogenic Proteins at the Nanoscale. [PDF]

ACS Omega
Bergaglio T, Kummer N, Bhattacharya S, Thompson D, Campioni S, Nirmalraj PN.   +5 more
europepmc   +1 more source

Modulation of Biological Membranes Using Small-Molecule Compounds to Counter Toxicity Caused by Amyloidogenic Proteins. [PDF]

Membranes (Basel)
Seychell RM, El Saghir A, Vassallo N.
europepmc   +1 more source

Interaction of Amyloidogenic Proteins with Membranes and Molecular Mechanism for the Development of Alzheimer's disease. [PDF]

Alzheimers Res Ther Open Access, 2019
Banerjee S, Lyubchenko YL.
europepmc   +1 more source

Naphthoquinone Tryptophan Hybrids: A Promising Small Molecule Scaffold for Mitigating Aggregation of Amyloidogenic Proteins and Peptides. [PDF]

Front Cell Dev Biol, 2019
Viswanathan GK, Paul A, Gazit E, Segal D.   +3 more
europepmc   +1 more source