Exploring cryptic amyloidogenic regions in prion-like proteins from plants
Frontiers in Plant Science, 2023 Prion-like domains (PrLDs) are intrinsically disordered regions (IDRs) of low sequence complexity with a similar composition to yeast prion domains. PrLDs-containing proteins have been involved in different organisms’ regulatory processes.
Carlos Pintado-Grima +7 more
doaj +1 more source
Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]
, 2012 Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S. +3 more
core +2 more sources
Interaction of Proteins Involved in Neuronal Proteinopathies
Life, 2023 Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease ...
Konstantin Y. Kulichikhin +4 more
doaj +1 more source
Protein dissection enhances the amyloidogenic properties of α‐lactalbumin [PDF]
The FEBS Journal, 2005 α‐lactalbumin (LA) in its molten globule (MG) state at low pH forms amyloid fibrils. Here, we have studied the aggregation propensities of LA derivatives characterized by a single peptide bond fission (1–40/41–123, named Th1‐LA) or a deletion of a chain segment of 12 amino acid residues located at the level of the β‐subdomain of the native protein (1 ...
POLVERINO DE LAURETO, PATRIZIA +5 more
openaire +4 more sources
Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
core +1 more source
EMBO Molecular Medicine, 2014 AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and fatal amyloid cardiomyopathy.
Jian Guan +12 more
doaj +1 more source
Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis. [PDF]
PLoS ONE, 2011 Amyloidoses constitute a group of diseases in which soluble proteins aggregate and deposit extracellularly in tissues. Nonhereditary apolipoprotein A-I (apoA-I) amyloid is characterized by deposits of nonvariant protein in atherosclerotic arteries ...
Nahuel A Ramella +8 more
doaj +1 more source
Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline [PDF]
, 2016 Acknowledgments We would like to gratefully acknowledge all donors and their families for the tissue provided for this study. Human tissue samples were supplied by the Brains for Dementia Research programme, jointly funded by Alzheimer’s Research UK, the
Cranston, Anna +5 more
core +3 more sources
Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis
Cell Reports, 2018 Summary: Amyloid bodies (A-bodies) are inducible membrane-less nuclear compartments composed of heterogeneous proteins that adopt an amyloid-like state. A-bodies are seeded by noncoding RNA derived from stimuli-specific loci of the rDNA intergenic spacer
Miling Wang +7 more
doaj +1 more source
Exploring Amyloidogenicity of Peptides From Ribosomal S1 Protein to Develop Novel AMPs
Frontiers in Molecular Biosciences, 2021 Antimicrobial peptides (AMPs) and similar compounds are potential candidates for combating antibiotic-resistant bacteria. The hypothesis of directed co-aggregation of the target protein and an amyloidogenic peptide acting as an antimicrobial peptide was ...
Oxana V. Galzitskaya +1 more
doaj +1 more source