Results 71 to 80 of about 69,622 (226)

Comparison of Cerebrospinal Fluid Amyloidogenic Nanoplaques With Core Biomarkers of Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2021
Accurate biomarkers of Alzheimer’s disease (AD) are essential for early diagnosis and intervention. Available biomarkers are not sufficient to permit the monitoring of AD progression over time, and additional biomarkers are required.
Mari Aksnes, Ann Tiiman, Trine Holt Edwin, Trine Holt Edwin, Trine Holt Edwin, Lars Terenius, Nenad Bogdanović, Vladana Vukojević, Anne-Brita Knapskog   +8 more
doaj   +1 more source

Dimensionality of Carbon Nanomaterials Determines the Binding and Dynamics of Amyloidogenic Peptides: Multiscale Theoretical Simulations [PDF]

, 2013
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and ...
A Albanese, A de Leon, A Gajewicz, A Hung, A Hung, A Hung, A Hung, A Hung, AA Mostofi, AA Shvedova, Ad Leon, Adam J. Makarucha, AJ Makarucha, AK Chamberlain, Arash A. Mostofi, AV Ghule, B Hess, B Roux, C Cabaleiro-Lago, C Li, C-K Skylaris, CA MacRaild, CA MacRaild, CC Chiu, CC Chiu, CK Skylaris, CK Skylaris, CL Teoh, D Frishman, D Van Der Spoel, DJ Cole, DM Hatters, EE Oren, G Lever, G Zuo, G Zuo, G Zuo, GB McGaughey, H Li, HC Fischer, HJC Berendsen, Irene Yarovsky, J Antony, J Dziedzic, J Kayat, J Lee, James M. Briggs, JP Perdew, JP Segrest, LJ Liang, LK Vesterdal, LM Wilson, LP Lee, M Mahmoudi, M Mahmoudi, M van der Zande, M Zhang, M Zhu, MDW Griffin, MP Monopoli, N Todorova, N Todorova, N Todorova, NDM Hine, Nevena Todorova, Nicholas D. M. Hine, Q Hill, Q Sun, R Cukalevski, R de la Rica, R Mout, RS D'Rozario, S De Miranda Tomásio, S Ehrlich, S Linse, SA Andujar, SA Love, SM Tomasio, ST Yang, TE Cheatham, TR Walsh, VC Sanchez, VL Colvin, VZ Poenitzsch, W Humphrey, WH Noon, Z Fu, Z Li, Z Yang   +88 more
core   +4 more sources

Microcanonical thermostatistics of coarse-grained proteins with amyloidogenic propensity [PDF]

The Journal of Chemical Physics, 2013
The formation of fibrillar aggregates seems to be a common characteristic of polypeptide chains, although the observation of these aggregates may depend on appropriate experimental conditions. Partially folded intermediates seem to have an important role in the generation of protein aggregates, and a mechanism for this fibril formation considers that ...
Frigori, Rafael B., Rizzi, Leandro G., Alves, Nelson A.   +2 more
openaire   +3 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide [PDF]

, 2016
Many chronic degenerative diseases result from aggregation of misfolded polypeptides to form amyloids. Many amyloidogenic polypeptides are surfactants and their assembly can be catalysed by hydrophobic-hydrophilic interfaces (an air-water interface in ...
Hawkins, N, Hodder, P, Jean, L, Lee, CF, Vaux, DJ   +4 more
core   +1 more source

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source

Influence of the stability of a fused protein and its distance to the amyloidogenic segment on fibril formation. [PDF]

PLoS ONE, 2010
Conversion of native proteins into amyloid fibrils is irreversible and therefore it is difficult to study the interdependence of conformational stability and fibrillation by thermodynamic analyses.
Anja Buttstedt, Reno Winter, Mirko Sackewitz, Gerd Hause, Franz-Xaver Schmid, Elisabeth Schwarz   +5 more
doaj   +1 more source

Inhibitory effect of natural flavone luteolin on Streptococcus mutans biofilm formation

Microbiology Spectrum, 2023
Streptococcus mutans is one of the key pathogens responsible for dental caries, which is known to be one of the most prevalent biofilm-associated diseases worldwide. S.
Lucille Rudin, Noelle Roth, Julien Kneubühler, Badri Nath Dubey, Michael M. Bornstein, Viktoriya Shyp   +5 more
doaj   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Theoretical analysis of amyloidogenic potential of lysozyme, cytochrome C and apolipoprotein A-I

Біофізичний вісник, 2016
Using 8 web-algorithms, including Pasta2, AmylPred2, Tango, MetAmyl, Waltz, Aggrescan, BetaScan та FoldAmyloid, theoretical analysis of amino acid sequences of lysozyme, cytochrome c and N-terminal fragment of apolipoprotein A-I has been carried out, and
В. М. Трусова
doaj